N-(2,6-difluoro-3-hydroxyphenyl)-6-fluoro-3-(3-fluorophenyl)-2-methylbenzamide

Base Information

Chemical Name:N-(2,6-difluoro-3-hydroxyphenyl)-6-fluoro-3-(3-fluorophenyl)-2-methylbenzamide
CAS No.:1427407-60-0
Molecular Formula:C₂₀H₁₃F₄NO₂
Molecular Weight:375.322
Hs Code.:

Synonyms:N-(2,6-difluoro-3-hydroxyphenyl)-6-fluoro-3-(3-fluorophenyl)-2-methylbenzamide

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of N-(2,6-difluoro-3-hydroxyphenyl)-6-fluoro-3-(3-fluorophenyl)-2-methylbenzamide

Chemical Property:

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Technology Process of N-(2,6-difluoro-3-hydroxyphenyl)-6-fluoro-3-(3-fluorophenyl)-2-methylbenzamide

There total 4 articles about N-(2,6-difluoro-3-hydroxyphenyl)-6-fluoro-3-(3-fluorophenyl)-2-methylbenzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1427330-97-9
3-amino-2 ,4-difluoro-phenol

: C₁₄H₉ClF₂O

: 1427407-60-0
N-(2,6-difluoro-3-hydroxyphenyl)-6-fluoro-3-(3-fluorophenyl)-2-methylbenzamide

Guidance literature:: With sodium hydrogencarbonate; In tetrahydrofuran; at 20 ℃; for 0.5h;

Reference yield:

: 90259-27-1
2-fluoro-6-methylbenzoic acid

: 1427407-60-0
N-(2,6-difluoro-3-hydroxyphenyl)-6-fluoro-3-(3-fluorophenyl)-2-methylbenzamide

Guidance literature:: Multi-step reaction with 4 steps

1: nitric acid; silver nitrate / water; acetic acid / 1.75 h / 20 °C

2: sodium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾ / N,N-dimethyl-formamide / 95 °C / Inert atmosphere

3: thionyl chloride / 80 °C

4: sodium hydrogencarbonate / tetrahydrofuran / 0.5 h / 20 °C

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; thionyl chloride; nitric acid; sodium hydrogencarbonate; sodium carbonate; silver nitrate; In tetrahydrofuran; water; acetic acid; N,N-dimethyl-formamide;

Reference yield:

: 1427407-59-7
6-fluoro-3-(3-fluorophenyl)-2-methylbenzoic acid

: 1427407-60-0
N-(2,6-difluoro-3-hydroxyphenyl)-6-fluoro-3-(3-fluorophenyl)-2-methylbenzamide

Guidance literature:: Multi-step reaction with 2 steps

1: thionyl chloride / 80 °C

2: sodium hydrogencarbonate / tetrahydrofuran / 0.5 h / 20 °C

With thionyl chloride; sodium hydrogencarbonate; In tetrahydrofuran;