(1R,2S,5R)-2-[1-((R)-4-Benzyl-3,4-dihydro-1H-isoquinolin-2-yl)-1-methyl-ethyl]-5-methyl-cyclohexanol

Base Information

Chemical Name:(1R,2S,5R)-2-[1-((R)-4-Benzyl-3,4-dihydro-1H-isoquinolin-2-yl)-1-methyl-ethyl]-5-methyl-cyclohexanol
CAS No.:350508-59-7
Molecular Formula:C₂₆H₃₅NO
Molecular Weight:377.57
Hs Code.:

Synonyms:(1R,2S,5R)-2-[1-((R)-4-Benzyl-3,4-dihydro-1H-isoquinolin-2-yl)-1-methyl-ethyl]-5-methyl-cyclohexanol

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Chemical Property of (1R,2S,5R)-2-[1-((R)-4-Benzyl-3,4-dihydro-1H-isoquinolin-2-yl)-1-methyl-ethyl]-5-methyl-cyclohexanol

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Technology Process of (1R,2S,5R)-2-[1-((R)-4-Benzyl-3,4-dihydro-1H-isoquinolin-2-yl)-1-methyl-ethyl]-5-methyl-cyclohexanol

There total 10 articles about (1R,2S,5R)-2-[1-((R)-4-Benzyl-3,4-dihydro-1H-isoquinolin-2-yl)-1-methyl-ethyl]-5-methyl-cyclohexanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 334706-84-2
(5R,7aS,10R,11aR,12aS)-5-Benzyl-7,7,10-trimethyl-5,7a,8,9,10,11,11a,12a-octahydro-6H,7H-12-oxa-6a-aza-benzo[a]anthracene

: 350508-59-7
(1R,2S,5R)-2-[1-((R)-4-Benzyl-3,4-dihydro-1H-isoquinolin-2-yl)-1-methyl-ethyl]-5-methyl-cyclohexanol

Guidance literature:: With lithium aluminium tetrahydride; aluminium trichloride; In tetrahydrofuran; at 0 ℃; for 0.5h;
DOI:10.1016/S0040-4020(01)00274-5

Reference yield:

: 55179-51-6
(-)-aminomenthol

: 350508-59-7
(1R,2S,5R)-2-[1-((R)-4-Benzyl-3,4-dihydro-1H-isoquinolin-2-yl)-1-methyl-ethyl]-5-methyl-cyclohexanol

Guidance literature:: Multi-step reaction with 4 steps

1.1: 98 percent / CH₂Cl₂ / 20 °C

2.1: 92 percent / K₂CO₃ / acetonitrile / Heating

3.1: t-BuLi / diethyl ether; pentane / 0.17 h / -90 °C

3.2: 77 percent / TMEDA / diethyl ether; pentane / 0.33 h / -90 - 20 °C

4.1: LiAlH₄; AlCl₃ / tetrahydrofuran / 0.33 h / -10 °C

With lithium aluminium tetrahydride; aluminium trichloride; tert.-butyl lithium; potassium carbonate; In tetrahydrofuran; diethyl ether; dichloromethane; acetonitrile; pentane;
DOI:10.1021/ja002864q

Reference yield:

: 6630-33-7
ortho-bromobenzaldehyde

: 350508-59-7
(1R,2S,5R)-2-[1-((R)-4-Benzyl-3,4-dihydro-1H-isoquinolin-2-yl)-1-methyl-ethyl]-5-methyl-cyclohexanol

Guidance literature:: Multi-step reaction with 4 steps

1.1: 98 percent / CH₂Cl₂ / 20 °C

2.1: 92 percent / K₂CO₃ / acetonitrile / Heating

3.1: t-BuLi / diethyl ether; pentane / 0.17 h / -90 °C

3.2: 77 percent / TMEDA / diethyl ether; pentane / 0.33 h / -90 - 20 °C

4.1: LiAlH₄; AlCl₃ / tetrahydrofuran / 0.33 h / -10 °C

With lithium aluminium tetrahydride; aluminium trichloride; tert.-butyl lithium; potassium carbonate; In tetrahydrofuran; diethyl ether; dichloromethane; acetonitrile; pentane;
DOI:10.1021/ja002864q