tert-butyl N-[1-[[5-[benzenesulfonyl(methyl)amino]-6-(2-phenylethynyl)-pyridin-2-yl]amino]-1-oxopropan-2-yl]-N-methylcarbamate

Base Information

Chemical Name:tert-butyl N-[1-[[5-[benzenesulfonyl(methyl)amino]-6-(2-phenylethynyl)-pyridin-2-yl]amino]-1-oxopropan-2-yl]-N-methylcarbamate
CAS No.:1452573-74-8
Molecular Formula:C₂₉H₃₂N₄O₅S
Molecular Weight:548.663
Hs Code.:

Synonyms:tert-butyl N-[1-[[5-[benzenesulfonyl(methyl)amino]-6-(2-phenylethynyl)-pyridin-2-yl]amino]-1-oxopropan-2-yl]-N-methylcarbamate

Suppliers and Price of tert-butyl N-[1-[[5-[benzenesulfonyl(methyl)amino]-6-(2-phenylethynyl)-pyridin-2-yl]amino]-1-oxopropan-2-yl]-N-methylcarbamate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of tert-butyl N-[1-[[5-[benzenesulfonyl(methyl)amino]-6-(2-phenylethynyl)-pyridin-2-yl]amino]-1-oxopropan-2-yl]-N-methylcarbamate

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of tert-butyl N-[1-[[5-[benzenesulfonyl(methyl)amino]-6-(2-phenylethynyl)-pyridin-2-yl]amino]-1-oxopropan-2-yl]-N-methylcarbamate

There total 6 articles about tert-butyl N-[1-[[5-[benzenesulfonyl(methyl)amino]-6-(2-phenylethynyl)-pyridin-2-yl]amino]-1-oxopropan-2-yl]-N-methylcarbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 13734-31-1
(S)-N-tert-butoxycarbonyl-N-methyl-2-amino-propionic acid

: 1452573-51-1
N-[6-amino-2-(2-phenylethynyl)pyridin-3-yl]-N-methylbenzenesulfonamide

: 1452573-74-8
tert-butyl N-[1-[[5-[benzenesulfonyl(methyl)amino]-6-(2-phenylethynyl)-pyridin-2-yl]amino]-1-oxopropan-2-yl]-N-methylcarbamate

Guidance literature:: (S)-N-tert-butoxycarbonyl-N-methyl-2-amino-propionic acid; With dicyclohexyl-carbodiimide; In dichloromethane; at 20 ℃; for 0.333333h;

N-[6-amino-2-(2-phenylethynyl)pyridin-3-yl]-N-methylbenzenesulfonamide; With N-ethyl-N,N-diisopropylamine; In dichloromethane; at 40 ℃; for 96h;

Reference yield:

: 536-74-3
phenylacetylene

: 1452573-74-8
tert-butyl N-[1-[[5-[benzenesulfonyl(methyl)amino]-6-(2-phenylethynyl)-pyridin-2-yl]amino]-1-oxopropan-2-yl]-N-methylcarbamate

Guidance literature:: Multi-step reaction with 5 steps

1.1: (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; copper(l) iodide; triethylamine / acetonitrile; tetrahydrofuran / 2 h / 20 °C / Inert atmosphere

2.1: pyridine / dichloromethane / 1 h / 20 °C

3.1: trifluoroacetic acid / dichloromethane / 2 h / 20 °C

4.1: sodium hydride / tetrahydrofuran; mineral oil / 0.17 h / 20 °C

4.2: 1 h / 20 °C

5.1: dicyclohexyl-carbodiimide / dichloromethane / 0.33 h / 20 °C

5.2: 96 h / 40 °C

With pyridine; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; copper(l) iodide; sodium hydride; triethylamine; dicyclohexyl-carbodiimide; trifluoroacetic acid; In tetrahydrofuran; dichloromethane; acetonitrile; mineral oil;

Reference yield:

: 1452573-06-6
tert-butyl-N-[5-amino-6-(2-phenylethynyl)pyridin-2-yl]carbamate

: 1452573-74-8
tert-butyl N-[1-[[5-[benzenesulfonyl(methyl)amino]-6-(2-phenylethynyl)-pyridin-2-yl]amino]-1-oxopropan-2-yl]-N-methylcarbamate

Guidance literature:: Multi-step reaction with 4 steps

1.1: pyridine / dichloromethane / 1 h / 20 °C

2.1: trifluoroacetic acid / dichloromethane / 2 h / 20 °C

3.1: sodium hydride / tetrahydrofuran; mineral oil / 0.17 h / 20 °C

3.2: 1 h / 20 °C

4.1: dicyclohexyl-carbodiimide / dichloromethane / 0.33 h / 20 °C

4.2: 96 h / 40 °C

With pyridine; sodium hydride; dicyclohexyl-carbodiimide; trifluoroacetic acid; In tetrahydrofuran; dichloromethane; mineral oil;