1,1-dimethylethyl [3-(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)-3-phenylpropyl]methylcarbamate

Base Information

Chemical Name:1,1-dimethylethyl [3-(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)-3-phenylpropyl]methylcarbamate
CAS No.:1047644-75-6
Molecular Formula:C₂₃H₂₆N₂O₄
Molecular Weight:394.47
Hs Code.:

Synonyms:1,1-dimethylethyl [3-(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)-3-phenylpropyl]methylcarbamate

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Chemical Property of 1,1-dimethylethyl [3-(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)-3-phenylpropyl]methylcarbamate

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Technology Process of 1,1-dimethylethyl [3-(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)-3-phenylpropyl]methylcarbamate

There total 5 articles about 1,1-dimethylethyl [3-(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)-3-phenylpropyl]methylcarbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 65.0%

: 136918-14-4,85-41-6
phthalimide

: 244059-08-3
tert-butyl N-(3-hydroxy-3-phenylpropyl)-N-methylcarbamate

: 1047644-75-6
1,1-dimethylethyl [3-(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)-3-phenylpropyl]methylcarbamate

Guidance literature:: With triphenylphosphine; diethylazodicarboxylate; In tetrahydrofuran; at 20 ℃; for 0.5h;

Reference yield:

: 42142-52-9
3-methylamino-1-phenylpropan-1-ol

: 1047644-75-6
1,1-dimethylethyl [3-(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)-3-phenylpropyl]methylcarbamate

Guidance literature:: Multi-step reaction with 2 steps

1: 2.54 g / NaHCO₃ / methanol / 8 h / Irradiation

2: 822 mg / DEAD, Ph₃P / tetrahydrofuran / 16 h / Ambient temperature

With sodium hydrogencarbonate; triphenylphosphine; diethylazodicarboxylate; In tetrahydrofuran; methanol;
DOI:10.1021/jm9811155

Reference yield:

: 936-59-4
3-chloropropiophenone

: 1047644-75-6
1,1-dimethylethyl [3-(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)-3-phenylpropyl]methylcarbamate

Guidance literature:: Multi-step reaction with 4 steps

1: B₂H₆ / tetrahydrofuran

2: 1.89 g / H₂O; ethanol / 16 h

3: 2.54 g / NaHCO₃ / methanol / 8 h / Irradiation

4: 822 mg / DEAD, Ph₃P / tetrahydrofuran / 16 h / Ambient temperature

With sodium hydrogencarbonate; triphenylphosphine; diborane; diethylazodicarboxylate; In tetrahydrofuran; methanol; ethanol; water;
DOI:10.1021/jm9811155