4-Nitro-benzoic acid (S)-7-benzenesulfonyl-1-[(2R,3R)-2-(tert-butyl-dimethyl-silanyloxy)-3-(4-methoxy-benzyloxy)-butyl]-6,6-dimethyl-5-oxo-heptyl ester

Base Information

• Chemical Name: 4-Nitro-benzoic acid (S)-7-benzenesulfonyl-1-[(2R,3R)-2-(tert-butyl-dimethyl-silanyloxy)-3-(4-methoxy-benzyloxy)-butyl]-6,6-dimethyl-5-oxo-heptyl ester
• CAS No.: 247146-57-2
• Molecular Formula: C₄₀H₅₅NO₁₀SSi
• Molecular Weight: 770.029

Synonyms:4-Nitro-benzoic acid (S)-7-benzenesulfonyl-1-[(2R,3R)-2-(tert-butyl-dimethyl-silanyloxy)-3-(4-methoxy-benzyloxy)-butyl]-6,6-dimethyl-5-oxo-heptyl ester

Chemical Property of 4-Nitro-benzoic acid (S)-7-benzenesulfonyl-1-[(2R,3R)-2-(tert-butyl-dimethyl-silanyloxy)-3-(4-methoxy-benzyloxy)-butyl]-6,6-dimethyl-5-oxo-heptyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 4-Nitro-benzoic acid (S)-7-benzenesulfonyl-1-[(2R,3R)-2-(tert-butyl-dimethyl-silanyloxy)-3-(4-methoxy-benzyloxy)-butyl]-6,6-dimethyl-5-oxo-heptyl ester

There total 14 articles about 4-Nitro-benzoic acid (S)-7-benzenesulfonyl-1-[(2R,3R)-2-(tert-butyl-dimethyl-silanyloxy)-3-(4-methoxy-benzyloxy)-butyl]-6,6-dimethyl-5-oxo-heptyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

t-butyldimethylsiyl triflate (69739-34-0) + 4-Nitro-benzoic acid (S)-7-benzenesulfonyl-1-[(2R,3R)-2-hydroxy-3-(4-methoxy-benzyloxy)-butyl]-6,6-dimethyl-5-oxo-heptyl ester (215876-17-8) → 4-Nitro-benzoic acid (S)-7-benzenesulfonyl-1-[(2R,3R)-2-(tert-butyl-dimethyl-silanyloxy)-3-(4-methoxy-benzyloxy)-butyl]-6,6-dimethyl-5-oxo-heptyl ester (247146-57-2)

Guidance literature:

With 2,6-dimethylpyridine; In dichloromethane; at -15 ℃;

DOI:10.1002/(SICI)1521-3773(19980918)37:17<2354::AID-ANIE2354>3.0.CO;2-9

Reference yield:

(R)-1-Benzenesulfonyl-7-hydroxy-10-(4-methoxy-benzyloxy)-2,2-dimethyl-undecane-3,9-dione → 4-Nitro-benzoic acid (S)-7-benzenesulfonyl-1-[(2R,3R)-2-(tert-butyl-dimethyl-silanyloxy)-3-(4-methoxy-benzyloxy)-butyl]-6,6-dimethyl-5-oxo-heptyl ester (247146-57-2)

Guidance literature:

Multi-step reaction with 2 steps

1: 76 percent / SmI₂ / tetrahydrofuran / 0 °C

2: 2,6-lutidine / CH₂Cl₂ / -15 °C

With 2,6-dimethylpyridine; samarium diiodide; In tetrahydrofuran; dichloromethane; 1: Tischenko reduction / 2: silylation;

DOI:10.1021/ja990860j

Reference yield:

2-Phenylthiomethyl-2-methyl-1-propanol (51916-36-0) → 4-Nitro-benzoic acid (S)-7-benzenesulfonyl-1-[(2R,3R)-2-(tert-butyl-dimethyl-silanyloxy)-3-(4-methoxy-benzyloxy)-butyl]-6,6-dimethyl-5-oxo-heptyl ester (247146-57-2)

Guidance literature:

Multi-step reaction with 9 steps

1.1: m-CPBA / CH₂Cl₂ / 0 - 23 °C

2.1: (COCl)2; DMSO; Et₃N / CH₂Cl₂ / -78 - 0 °C

3.1: CH₂Cl₂; diethyl ether / 0 - 23 °C

4.1: 82 percent / (COCl)2; DMSO; Et₃N / CH₂Cl₂ / -78 - -50 °C / *

5.1: K₂OsO₄(OH₂)2; quinuclidine; aq. K₃Fe(CN)6 / 2-methyl-propan-2-ol

6.1: NaIO₄; aq. NaHCO₃ / 2-methyl-propan-2-ol; tetrahydrofuran

7.1: (-)-DIPCl; Et₃N / CH₂Cl₂ / -78 °C

7.2: 87 percent / -70 °C

8.1: 76 percent / SmI₂ / tetrahydrofuran / 0 °C

9.1: 2,6-lutidine / CH₂Cl₂ / -15 °C

With Quinuclidine; 2,6-dimethylpyridine; potassium osmate(VI); sodium periodate; samarium diiodide; oxalyl dichloride; sodium hydrogencarbonate; dimethyl sulfoxide; triethylamine; 3-chloro-benzenecarboperoxoic acid; (-)-diisopinocamphenylborane chloride; potassium hexacyanoferrate(III); In tetrahydrofuran; diethyl ether; dichloromethane; tert-butyl alcohol; 1.1: Oxidation / 2.1: Oxidation / 3.1: Grignard reaction / 4.1: Oxidation / 5.1: dihydroxylation / 6.1: diol cleavage / 7.1: chiral boronation / 7.2: Substitution / 8.1: Tischenko reduction / 9.1: silylation;

DOI:10.1021/ja990860j

upstream raw materials:

t-butyldimethylsiyl triflate

4-Nitro-benzoic acid (S)-7-benzenesulfonyl-1-[(2R,3R)-2-hydroxy-3-(4-methoxy-benzyloxy)-butyl]-6,6-dimethyl-5-oxo-heptyl ester

2-Phenylthiomethyl-2-methyl-1-propanol

3-hydroxy-2,2-dimethylpropyl 4-methylbenzenesulfonate

Downstream raw materials:

(7S,9R,10R)-1-Benzenesulfonyl-9-(tert-butyl-dimethyl-silanyloxy)-7-hydroxy-10-(4-methoxy-benzyloxy)-2,2-dimethyl-undecan-3-one

[1-[6-(2-benzenesulfonyl-1,1-dimethyl-ethyl)-3,4-dihydro-2H-pyran-2-ylmethyl]-2-(4-methoxy-benzyloxy)-propoxy]-tert-butyl-dimethyl-silane

[(2S,4R,6R)-4-(tert-Butyl-dimethyl-silanyloxy)-6-((E)-3-{(S)-6-[(2R,3R)-2-(tert-butyl-dimethyl-silanyloxy)-3-(4-methoxy-benzyloxy)-butyl]-5,6-dihydro-4H-pyran-2-yl}-3-methyl-but-1-enyl)-tetrahydro-pyran-2-yl]-methanol

6-{3-[4-(tert-butyl-dimethyl-silanyloxy)-6-(tert-butyl-dimethyl-silanyloxymethyl)-tetrahydro-pyran-2-yl]-1,1-dimethyl-allyl}-2-[2-(tert-butyl-dimethyl-silanyloxy)-3-(4-methoxy-benzyloxy)-butyl]-3,4-dihydro-2H-pyran

Post a RFQ

Cas No.:

Product Name:

Quantity:

Please select Metric Ton KG G Pound L ML

Email:

Company name:

Valid Period:

Detailed Requirements:

• Sample
• MOQ
• GMP
• FDA
• Price
  FOB CIF CFR EXW
• Urgent purchase

Enter 15 to 2000 letters.Word count: 0 letters

Attach files(File Format: Jpeg, Jpg, Gif, Png, PDF, PPT, Zip, Rar,Word or Excel Maximum File Size: 3MB)

Remove

Submit

1

What can I do for you?
Get Best Price

Get Best Price for 247146-57-2 4-Nitro-benzoic acid (S)-7-benzenesulfonyl-1-[(2R,3R)-2-(tert-butyl-dimethyl-silanyloxy)-3-(4-methoxy-benzyloxy)-butyl]-6,6-dimethyl-5-oxo-heptyl ester

Send

Send

Metric Ton KG G Pound L ML

Send

Send