(Bis-N,N'-(Cbz)-L-lysyl-D-threo-β-hydroxyaspartyl β-benzyl ester)-L-alanyl-D-allo-threonyl-L-alanine tert-butyl ester

Base Information

• Chemical Name: (Bis-N,N'-(Cbz)-L-lysyl-D-threo-β-hydroxyaspartyl β-benzyl ester)-L-alanyl-D-allo-threonyl-L-alanine tert-butyl ester
• CAS No.: 162553-94-8
• Molecular Formula: C₄₇H₆₂N₆O₁₄
• Molecular Weight: 935.041

Synonyms:(Bis-N,N'-(Cbz)-L-lysyl-D-threo-β-hydroxyaspartyl β-benzyl ester)-L-alanyl-D-allo-threonyl-L-alanine tert-butyl ester

Chemical Property of (Bis-N,N'-(Cbz)-L-lysyl-D-threo-β-hydroxyaspartyl β-benzyl ester)-L-alanyl-D-allo-threonyl-L-alanine tert-butyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (Bis-N,N'-(Cbz)-L-lysyl-D-threo-β-hydroxyaspartyl β-benzyl ester)-L-alanyl-D-allo-threonyl-L-alanine tert-butyl ester

There total 12 articles about (Bis-N,N'-(Cbz)-L-lysyl-D-threo-β-hydroxyaspartyl β-benzyl ester)-L-alanyl-D-allo-threonyl-L-alanine tert-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

tert-butyl L-alaninate hydrochloride (13404-22-3) → (Bis-N,N'-(Cbz)-L-lysyl-D-threo-β-hydroxyaspartyl β-benzyl ester)-L-alanyl-D-allo-threonyl-L-alanine tert-butyl ester (162553-94-8)

Guidance literature:

Multi-step reaction with 6 steps

1: 2-ethoxy-1-(ethoxycarbonyl)-1,2-dihydroquinoline, Et₃N / acetonitrile / Ambient temperature

2: H₂ / 10percent Pd/C / methanol / 3 h

3: 2-ethoxy-1-(ethoxycarbonyl)-1,2-dihydroquinoline / CHCl₃ / 48 h / Ambient temperature

4: 1.) CH₃O₂CNSO₂NEt₃, 2.) 1 N aq. HCl / 1.) THF, 70 deg C, 2 h, 2.) r.t., 30 min

5: H₂ / 10percent Pd/C / methanol / 3 h

6: 2-ethoxy-1-(ethoxycarbonyl)-1,2-dihydroquinoline / CHCl₃ / 20 h / Ambient temperature

With hydrogenchloride; Burgess Reagent; hydrogen; N-ethoxycarbonyl-2-ethoxy-1,2-dihydroquinoline; triethylamine; palladium on activated charcoal; In methanol; chloroform; acetonitrile;

DOI:10.1021/jo00112a009

Reference yield:

(S)-2-((2R,3S)-2-Amino-3-hydroxy-butyrylamino)-propionic acid tert-butyl ester → (Bis-N,N'-(Cbz)-L-lysyl-D-threo-β-hydroxyaspartyl β-benzyl ester)-L-alanyl-D-allo-threonyl-L-alanine tert-butyl ester (162553-94-8)

Guidance literature:

Multi-step reaction with 4 steps

1: 2-ethoxy-1-(ethoxycarbonyl)-1,2-dihydroquinoline / CHCl₃ / 48 h / Ambient temperature

2: 1.) CH₃O₂CNSO₂NEt₃, 2.) 1 N aq. HCl / 1.) THF, 70 deg C, 2 h, 2.) r.t., 30 min

3: H₂ / 10percent Pd/C / methanol / 3 h

4: 2-ethoxy-1-(ethoxycarbonyl)-1,2-dihydroquinoline / CHCl₃ / 20 h / Ambient temperature

With hydrogenchloride; Burgess Reagent; hydrogen; N-ethoxycarbonyl-2-ethoxy-1,2-dihydroquinoline; palladium on activated charcoal; In methanol; chloroform;

DOI:10.1021/jo00112a009

Reference yield:

(S)-2-((2R,3R)-2-Amino-3-hydroxy-butyrylamino)-propionic acid tert-butyl ester → (Bis-N,N'-(Cbz)-L-lysyl-D-threo-β-hydroxyaspartyl β-benzyl ester)-L-alanyl-D-allo-threonyl-L-alanine tert-butyl ester (162553-94-8)

Guidance literature:

Multi-step reaction with 3 steps

1: 2-ethoxy-1-(ethoxycarbonyl)-1,2-dihydroquinoline / CHCl₃ / 48 h / Ambient temperature

2: H₂ / 10percent Pd/C / methanol / 3 h

3: 2-ethoxy-1-(ethoxycarbonyl)-1,2-dihydroquinoline / CHCl₃ / 20 h / Ambient temperature

With hydrogen; N-ethoxycarbonyl-2-ethoxy-1,2-dihydroquinoline; palladium on activated charcoal; In methanol; chloroform;

DOI:10.1021/jo00112a009

upstream raw materials:

(S)-2-[(2R,3R)-2-((S)-2-Amino-propionylamino)-3-hydroxy-butyrylamino]-propionic acid tert-butyl ester

Bis-N,N'-(Cbz)-L-lysyl-β-benzyl D-threo-β-hydroxyaspartate

N_α,N_ε-bis(carbobenzyloxy)-L-lysine N-hydroxysuccinimide ester

N,N'-di-[(phenylmethoxy)carbonyl]-L-lysine

Downstream raw materials:

(Bis-N,N'-(Cbz)-L-lysyl-D-threo-β-hydroxyaspartyl β-benzyl ester)-L-alanyl-D-allo-threonyl-L-alanyl-δ-N-(benzyloxy)-D-cycloornithine

(2R,3R)-3-((S)-2,6-Bis-benzyloxycarbonylamino-hexanoylamino)-N-{(S)-1-[(1R,2R)-1-((S)-1-carboxy-ethylcarbamoyl)-2-hydroxy-propylcarbamoyl]-ethyl}-2-hydroxy-succinamic acid benzyl ester

Post a RFQ

Cas No.:

Product Name:

Quantity:

Please select Metric Ton KG G Pound L ML

Email:

Company name:

Valid Period:

Detailed Requirements:

• Sample
• MOQ
• GMP
• FDA
• Price
  FOB CIF CFR EXW
• Urgent purchase

Enter 15 to 2000 letters.Word count: 0 letters

Attach files(File Format: Jpeg, Jpg, Gif, Png, PDF, PPT, Zip, Rar,Word or Excel Maximum File Size: 3MB)

Remove

Submit

1

What can I do for you?
Get Best Price

Get Best Price for 162553-94-8 (Bis-N,N'-(Cbz)-L-lysyl-D-threo-β-hydroxyaspartyl β-benzyl ester)-L-alanyl-D-allo-threonyl-L-alanine tert-butyl ester

Send

Send

Metric Ton KG G Pound L ML

Send

Send