5-(2-chloro-4-methoxyphenyl)-N-(1-ethylpropyl)-6-methyl-2,3-dihydrofuro[3,2-d]pyrazolo[1,5-a]pyrimidin-9-amine

Base Information

Chemical Name:5-(2-chloro-4-methoxyphenyl)-N-(1-ethylpropyl)-6-methyl-2,3-dihydrofuro[3,2-d]pyrazolo[1,5-a]pyrimidin-9-amine
CAS No.:1338727-94-8
Molecular Formula:C₂₁H₂₅ClN₄O₂
Molecular Weight:400.908
Hs Code.:

Synonyms:5-(2-chloro-4-methoxyphenyl)-N-(1-ethylpropyl)-6-methyl-2,3-dihydrofuro[3,2-d]pyrazolo[1,5-a]pyrimidin-9-amine

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Chemical Property of 5-(2-chloro-4-methoxyphenyl)-N-(1-ethylpropyl)-6-methyl-2,3-dihydrofuro[3,2-d]pyrazolo[1,5-a]pyrimidin-9-amine

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Technology Process of 5-(2-chloro-4-methoxyphenyl)-N-(1-ethylpropyl)-6-methyl-2,3-dihydrofuro[3,2-d]pyrazolo[1,5-a]pyrimidin-9-amine

There total 5 articles about 5-(2-chloro-4-methoxyphenyl)-N-(1-ethylpropyl)-6-methyl-2,3-dihydrofuro[3,2-d]pyrazolo[1,5-a]pyrimidin-9-amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: C₁₆H₁₃Cl₂N₃O₂

: 616-24-0
3-aminopentane

: 1338727-94-8
5-(2-chloro-4-methoxyphenyl)-N-(1-ethylpropyl)-6-methyl-2,3-dihydrofuro[3,2-d]pyrazolo[1,5-a]pyrimidin-9-amine

Guidance literature:: In isopropyl alcohol; at 20 - 90 ℃; for 4h;
DOI:10.1016/j.bmc.2011.07.055

Reference yield:

: C₁₆H₁₄ClN₃O₃

: 1338727-94-8
5-(2-chloro-4-methoxyphenyl)-N-(1-ethylpropyl)-6-methyl-2,3-dihydrofuro[3,2-d]pyrazolo[1,5-a]pyrimidin-9-amine

Guidance literature:: Multi-step reaction with 2 steps

1: N,N-diethylaniline; trichlorophosphate / toluene / 5 h / 20 °C / Reflux

2: isopropyl alcohol / 4 h / 20 - 90 °C

With N,N-diethylaniline; trichlorophosphate; In isopropyl alcohol; toluene;
DOI:10.1016/j.bmc.2011.07.055

Reference yield:

: 170737-93-6
2-chloro-4-methoxyphenylacetonitrile

: 1338727-94-8
5-(2-chloro-4-methoxyphenyl)-N-(1-ethylpropyl)-6-methyl-2,3-dihydrofuro[3,2-d]pyrazolo[1,5-a]pyrimidin-9-amine

Guidance literature:: Multi-step reaction with 5 steps

1.1: sodium / 20 °C / Reflux

2.1: hydrazine hydrate; acetic acid / toluene / 3 h / 20 °C / Reflux

2.2: pH 11

3.1: acetic acid / 3 h / Reflux

4.1: N,N-diethylaniline; trichlorophosphate / toluene / 5 h / 20 °C / Reflux

5.1: isopropyl alcohol / 4 h / 20 - 90 °C

With sodium; hydrazine hydrate; acetic acid; N,N-diethylaniline; trichlorophosphate; In isopropyl alcohol; toluene;
DOI:10.1016/j.bmc.2011.07.055