(2S)-tert-Butyl 5-phenyl-5-oxo-2-amino>pentanoate

Base Information

Chemical Name:(2S)-tert-Butyl 5-phenyl-5-oxo-2-amino>pentanoate
CAS No.:152381-76-5
Molecular Formula:C₃₄H₃₃NO₃
Molecular Weight:503.641
Hs Code.:

(2S)-tert-Butyl 5-phenyl-5-oxo-2-<N-<9-(9-phenylfluorenyl)>amino>pentanoate

Synonyms:(2S)-tert-Butyl 5-phenyl-5-oxo-2-amino>pentanoate

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (2S)-tert-Butyl 5-phenyl-5-oxo-2-amino>pentanoate

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Technology Process of (2S)-tert-Butyl 5-phenyl-5-oxo-2-amino>pentanoate

There total 7 articles about (2S)-tert-Butyl 5-phenyl-5-oxo-2-amino>pentanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

: (S)-2-Benzoyl-4-(9-phenyl-9H-fluoren-9-ylamino)-pentanedioic acid 5-tert-butyl ester 1-methyl ester

: 152381-76-5
(2S)-tert-Butyl 5-phenyl-5-oxo-2-amino>pentanoate

Guidance literature:: With lithium hydroxide; In tetrahydrofuran; Heating;
DOI:10.1021/jo00075a046

Reference yield:

: 119595-73-2
L-α-tert-butyl γ-methyl N-(9-(9-phenylfluorenyl))glutamate

: 152381-76-5
(2S)-tert-Butyl 5-phenyl-5-oxo-2-amino>pentanoate

Guidance literature:: Multi-step reaction with 2 steps

1: 90 percent / n-BuLi, 1,1,1,3,3,3-hexamethyldisilazane / tetrahydrofuran / 1.) -78 deg C, 1 h, 2.) -78 deg C, 1.5 h

2: 90 percent / 2 M aq. LiOH / tetrahydrofuran / Heating

With lithium hydroxide; n-butyllithium; 1,1,1,3,3,3-hexamethyl-disilazane; In tetrahydrofuran;
DOI:10.1021/jo00075a046

Reference yield:

: 1499-55-4
L-glutamic acid 5-methyl ester

: 152381-76-5
(2S)-tert-Butyl 5-phenyl-5-oxo-2-amino>pentanoate

Guidance literature:: Multi-step reaction with 5 steps

1: CHCl₃ / 2 h / Heating

2: lead nitrate, Et₃N / CHCl₃ / 87 h / Ambient temperature

3: 75 percent / CH₂Cl₂ / 16 h / Ambient temperature

4: 1.) potassium hexamethyldisilazide (KHMDS), 2.) η⁶-benzene chromium tricarbonyl, 3.) I2

5: tetrahydrofuran / -78 - 20 °C

With lead(II) nitrate; iodine; potassium hexamethylsilazane; triethylamine; In tetrahydrofuran; dichloromethane; chloroform;
DOI:10.1021/jo00269a022