4-benzyloxy-2-(1-dimethylaminomethylidene)-3-oxo-butyric acid ethyl ester

Base Information

Chemical Name:4-benzyloxy-2-(1-dimethylaminomethylidene)-3-oxo-butyric acid ethyl ester
CAS No.:727382-68-5
Molecular Formula:C₁₆H₂₁NO₄
Molecular Weight:291.347
Hs Code.:

Synonyms:4-benzyloxy-2-(1-dimethylaminomethylidene)-3-oxo-butyric acid ethyl ester

Suppliers and Price of 4-benzyloxy-2-(1-dimethylaminomethylidene)-3-oxo-butyric acid ethyl ester

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Matrix Scientific
4-Benzyloxy-2-dimethylaminomethylene-3-oxo-butyric acid ethyl ester 95%
5g
$ 1486.00

A1 Biochem Labs
4-Benzyloxy-2-dimethylaminomethylene-3-oxo-butyricacidethylester 95%
1 g
$ 500.00

Total 2 raw suppliers

Chemical Property of 4-benzyloxy-2-(1-dimethylaminomethylidene)-3-oxo-butyric acid ethyl ester

Chemical Property:

Purity/Quality:

98% ^*data from raw suppliers

4-Benzyloxy-2-dimethylaminomethylene-3-oxo-butyric acid ethyl ester 95% ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of 4-benzyloxy-2-(1-dimethylaminomethylidene)-3-oxo-butyric acid ethyl ester

There total 6 articles about 4-benzyloxy-2-(1-dimethylaminomethylidene)-3-oxo-butyric acid ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 82.0%

: 67354-34-1
ethyl 4-benzyloxyacetoacetate

: 4637-24-5
N,N-dimethyl-formamide dimethyl acetal

: 727382-68-5
4-benzyloxy-2-(1-dimethylaminomethylidene)-3-oxo-butyric acid ethyl ester

Guidance literature:: In toluene;

Reference yield:

: 924-99-2,1117-37-9,114894-59-6
ethyl 3-(dimethylamino)acrylate

: 19810-31-2
Benzyloxyacetyl chloride

: 727382-68-5
4-benzyloxy-2-(1-dimethylaminomethylidene)-3-oxo-butyric acid ethyl ester

Guidance literature:: With pyridine; In dichloromethane; at 1 - 15 ℃; for 2.33333h;

Reference yield:

: 638-07-3
ethyl (2-chloroaceto)acetate

: 100-51-6,185532-71-2
benzyl alcohol

: 727382-68-5
4-benzyloxy-2-(1-dimethylaminomethylidene)-3-oxo-butyric acid ethyl ester

Guidance literature:: Multi-step reaction with 2 steps

1.1: sodium hydride / tetrahydrofuran / 2 h / 0 - 20 °C / Inert atmosphere

1.2: 20 °C / Inert atmosphere

2.1: toluene / 12 h / 20 °C / Inert atmosphere

With sodium hydride; In tetrahydrofuran; toluene;
DOI:10.1021/acs.jmedchem.6b00465