Phenethyl-(2-pyridin-2-yl-quinazolin-4-yl)-amine

Base Information

Chemical Name:Phenethyl-(2-pyridin-2-yl-quinazolin-4-yl)-amine
CAS No.:586984-06-7
Molecular Formula:C₂₁H₁₈N₄
Molecular Weight:326.401
Hs Code.:
DSSTox Substance ID:DTXSID801320512
Pharos Ligand ID:STJ8QFGUSDQ7
ChEMBL ID:CHEMBL1518085

Synonyms:MLS000769840;SMR000434573;Phenethyl-(2-pyridin-2-yl-quinazolin-4-yl)-amine;N-(2-phenylethyl)-2-pyridin-2-ylquinazolin-4-amine;cid_937982;SCHEMBL2905797;CHEMBL1518085;BDBM47468;DTXSID801320512;STK558250;AKOS005483971;586984-06-7;phenethyl-[2-(2-pyridyl)quinazolin-4-yl]amine;SR-01000766277;SR-01000766277-2;N-(2-phenylethyl)-2-(2-pyridinyl)-4-quinazolinamine;N-(2-phenylethyl)-2-pyridin-2-yl-quinazolin-4-amine;N-(2-phenylethyl)-2-(pyridin-2-yl)quinazolin-4-amine

Suppliers and Price of Phenethyl-(2-pyridin-2-yl-quinazolin-4-yl)-amine

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of Phenethyl-(2-pyridin-2-yl-quinazolin-4-yl)-amine

Chemical Property:

XLogP3:4.4
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:4
Rotatable Bond Count:5
Exact Mass:326.153146591
Heavy Atom Count:25
Complexity:395

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Canonical SMILES:C1=CC=C(C=C1)CCNC2=NC(=NC3=CC=CC=C32)C4=CC=CC=N4

Technology Process of Phenethyl-(2-pyridin-2-yl-quinazolin-4-yl)-amine

There total 5 articles about Phenethyl-(2-pyridin-2-yl-quinazolin-4-yl)-amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 64-04-0
phenethylamine

: 91748-47-9
4-Chloro-2-(pyridin-2-yl)-quinazoline

: 586984-06-7
N-phenethyl-2-(pyridin-2-yl)quinazolin-4-amine

Guidance literature:: With potassium carbonate; In isopropyl alcohol; toluene; Heating / reflux;

Reference yield:

: 28594-60-7
2-(2-pyridyl)-2,3-dihydroquinazolin-4-(1H)-one

: 586984-06-7
N-phenethyl-2-(pyridin-2-yl)quinazolin-4-amine

Guidance literature:: Multi-step reaction with 2 steps

1: N,N-diethylaniline; trichlorophosphate / benzene / 4 h / 100 °C

2: N-ethyl-N,N-diisopropylamine / 1,4-dioxane / 110 °C

With N-ethyl-N,N-diisopropylamine; N,N-diethylaniline; trichlorophosphate; In 1,4-dioxane; benzene;
DOI:10.1021/jm400227z

Reference yield:

: 100-70-9,1232006-36-8
2-Cyanopyridine

: 586984-06-7
N-phenethyl-2-(pyridin-2-yl)quinazolin-4-amine

Guidance literature:: Multi-step reaction with 3 steps

1.1: sodium / methanol / 25 °C

1.2: 18 h / 85 °C

2.1: N,N-diethylaniline; trichlorophosphate / benzene / 4 h / 100 °C

3.1: N-ethyl-N,N-diisopropylamine / 1,4-dioxane / 110 °C

With sodium; N-ethyl-N,N-diisopropylamine; N,N-diethylaniline; trichlorophosphate; In 1,4-dioxane; methanol; benzene;
DOI:10.1021/jm400227z