4,5-Dihydro-5-((4-(3,4-dimethoxyphenyl)-1-piperazinyl)methyl)-2-oxazolamine

Base Information

Chemical Name:4,5-Dihydro-5-((4-(3,4-dimethoxyphenyl)-1-piperazinyl)methyl)-2-oxazolamine
CAS No.:144722-86-1
Molecular Formula:C₁₆H₂₄N₄O₃
Molecular Weight:320.392
Hs Code.:
DSSTox Substance ID:DTXSID40932391
Nikkaji Number:J519.261G
Mol file:144722-86-1.mol

Synonyms:4,5-Dihydro-5-((4-(3,4-dimethoxyphenyl)-1-piperazinyl)methyl)-2-oxazolamine;2-Oxazolamine, 4,5-dihydro-5-((4-(3,4-dimethoxyphenyl)-1-piperazinyl)methyl)-;144722-86-1;DTXSID40932391;LS-100042;5-[[4-(3,4-Dimethoxyphenyl)piperazin-1-yl]methyl]oxazolidin-2-imine;5-{[4-(3,4-Dimethoxyphenyl)piperazin-1-yl]methyl}-1,3-oxazolidin-2-imine

Suppliers and Price of 4,5-Dihydro-5-((4-(3,4-dimethoxyphenyl)-1-piperazinyl)methyl)-2-oxazolamine

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 4,5-Dihydro-5-((4-(3,4-dimethoxyphenyl)-1-piperazinyl)methyl)-2-oxazolamine

Chemical Property:

Vapor Pressure:4.88E-10mmHg at 25°C
Boiling Point:497.6°Cat760mmHg
Flash Point:254.7°C
Density:1.3g/cm³
XLogP3:0.9
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:6
Rotatable Bond Count:5
Exact Mass:320.18484064
Heavy Atom Count:23
Complexity:412

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:COC1=C(C=C(C=C1)N2CCN(CC2)CC3CN=C(O3)N)OC

Technology Process of 4,5-Dihydro-5-((4-(3,4-dimethoxyphenyl)-1-piperazinyl)methyl)-2-oxazolamine

There total 4 articles about 4,5-Dihydro-5-((4-(3,4-dimethoxyphenyl)-1-piperazinyl)methyl)-2-oxazolamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 27.0%

: 19981-17-0,20611-81-8,123092-13-7,17292-62-5
sodium cyanamide

: 1026333-89-0
1-(3,4-Dimethoxy-phenyl)-4-oxiranylmethyl-piperazine

: 144722-86-1
5-[4-(3,4-Dimethoxy-phenyl)-piperazin-1-ylmethyl]-4,5-dihydro-oxazol-2-ylamine

Guidance literature:: In methanol; for 24h; Ambient temperature;
DOI:10.1016/0223-5234(92)90177-3

Reference yield:

: 16015-73-9
1-(3,4-dimethoxyphenyl)piperazine

: 144722-86-1
5-[4-(3,4-Dimethoxy-phenyl)-piperazin-1-ylmethyl]-4,5-dihydro-oxazol-2-ylamine

Guidance literature:: Multi-step reaction with 2 steps

1: ethanol / 24 h / Ambient temperature

2: methanol / 12 h / Ambient temperature

In methanol; ethanol;
DOI:10.1016/0223-5234(92)90177-3

Reference yield:

: 1025886-16-1
1-Chloro-3-[4-(3,4-dimethoxy-phenyl)-piperazin-1-yl]-propan-2-ol

: 144722-86-1
5-[4-(3,4-Dimethoxy-phenyl)-piperazin-1-ylmethyl]-4,5-dihydro-oxazol-2-ylamine

Guidance literature:: Multi-step reaction with 2 steps

1: NaOH / ethanol / 15 h / Ambient temperature

2: 27 percent / methanol / 24 h / Ambient temperature

With sodium hydroxide; In methanol; ethanol;
DOI:10.1016/0223-5234(92)90177-3