5-(4-chlorophenyl)-2-(dimethylamino)-6-((1s,4s)-4-(trifluoromethyl)cyclohexyl)-pyrimidin-4(3H)-one

Base Information

Chemical Name:5-(4-chlorophenyl)-2-(dimethylamino)-6-((1s,4s)-4-(trifluoromethyl)cyclohexyl)-pyrimidin-4(3H)-one
CAS No.:1175078-40-6
Molecular Formula:C₁₉H₂₁ClF₃N₃O
Molecular Weight:399.843
Hs Code.:

Synonyms:5-(4-chlorophenyl)-2-(dimethylamino)-6-((1s,4s)-4-(trifluoromethyl)cyclohexyl)-pyrimidin-4(3H)-one

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Chemical Property of 5-(4-chlorophenyl)-2-(dimethylamino)-6-((1s,4s)-4-(trifluoromethyl)cyclohexyl)-pyrimidin-4(3H)-one

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Technology Process of 5-(4-chlorophenyl)-2-(dimethylamino)-6-((1s,4s)-4-(trifluoromethyl)cyclohexyl)-pyrimidin-4(3H)-one

There total 3 articles about 5-(4-chlorophenyl)-2-(dimethylamino)-6-((1s,4s)-4-(trifluoromethyl)cyclohexyl)-pyrimidin-4(3H)-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1175078-66-6
methyl 2-(4-chlorophenyl)-3-oxo-3-[4-(trifluoromethyl)cyclohexyl]propanoate

: 311-77-3,1186-46-5
1,1-dimethylguanidine dihydrogensulfate

: 1175078-40-6
5-(4-chlorophenyl)-2-(dimethylamino)-6-((1s,4s)-4-(trifluoromethyl)cyclohexyl)-pyrimidin-4(3H)-one

Guidance literature:: methyl 2-(4-chlorophenyl)-3-oxo-3-[4-(trifluoromethyl)cyclohexyl]propanoate; 1,1-dimethylguanidine dihydrogensulfate; With ethanol; sodium; for 5h; Heating; Reflux;

With hydrogenchloride; In water; pH=7;

Reference yield:

: 477905-43-4
4-(trifluoromethyl)cyclohexanecarbonyl chloride

: 1175078-40-6
5-(4-chlorophenyl)-2-(dimethylamino)-6-((1s,4s)-4-(trifluoromethyl)cyclohexyl)-pyrimidin-4(3H)-one

Guidance literature:: Multi-step reaction with 2 steps

1.1: lithium hexamethyldisilazane / tetrahydrofuran / -78 - 20 °C / Inert atmosphere

1.2: -78 - 0 °C / Inert atmosphere

2.1: ethanol; sodium / 5 h / Heating; Reflux

2.2: pH 7

With ethanol; sodium; lithium hexamethyldisilazane; In tetrahydrofuran;

Reference yield:

: 72770-09-3
4-(chloromethyl)-phenylacetic methylester

: 1175078-40-6
5-(4-chlorophenyl)-2-(dimethylamino)-6-((1s,4s)-4-(trifluoromethyl)cyclohexyl)-pyrimidin-4(3H)-one

Guidance literature:: Multi-step reaction with 2 steps

1.1: lithium hexamethyldisilazane / tetrahydrofuran / -78 - 20 °C / Inert atmosphere

1.2: -78 - 0 °C / Inert atmosphere

2.1: ethanol; sodium / 5 h / Heating; Reflux

2.2: pH 7

With ethanol; sodium; lithium hexamethyldisilazane; In tetrahydrofuran;