(R)-4-((7-(4-hydroxy-3-methoxyphenyl)-1,6-naphthyridine-5-yloxy)methyl)pyrrolidine-2-one

Base Information

Chemical Name:(R)-4-((7-(4-hydroxy-3-methoxyphenyl)-1,6-naphthyridine-5-yloxy)methyl)pyrrolidine-2-one
CAS No.:1319737-92-2
Molecular Formula:C₂₀H₁₉N₃O₄
Molecular Weight:365.389
Hs Code.:

Synonyms:(R)-4-((7-(4-hydroxy-3-methoxyphenyl)-1,6-naphthyridine-5-yloxy)methyl)pyrrolidine-2-one

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Chemical Property of (R)-4-((7-(4-hydroxy-3-methoxyphenyl)-1,6-naphthyridine-5-yloxy)methyl)pyrrolidine-2-one

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Technology Process of (R)-4-((7-(4-hydroxy-3-methoxyphenyl)-1,6-naphthyridine-5-yloxy)methyl)pyrrolidine-2-one

There total 3 articles about (R)-4-((7-(4-hydroxy-3-methoxyphenyl)-1,6-naphthyridine-5-yloxy)methyl)pyrrolidine-2-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: C₃₆H₃₅N₃O₅

: 1319737-92-2
(R)-4-((7-(4-hydroxy-3-methoxyphenyl)-1,6-naphthyridine-5-yloxy)methyl)pyrrolidine-2-one

Guidance literature:: C₃₆H₃₅N₃O₅; With trifluoroacetic acid; at 20 ℃;

With trifluoroacetic acid; at 150 ℃; for 0.583333h; Microwave irradiation;

With ammonia; In methanol; dichloromethane;

Reference yield:

: 99735-43-0,96449-93-3,99735-44-1
(3R)-1-((R)-1-phenylethyl)-5-oxo-3-pyrrolidinecarboxylic acid

: 1319737-92-2
(R)-4-((7-(4-hydroxy-3-methoxyphenyl)-1,6-naphthyridine-5-yloxy)methyl)pyrrolidine-2-one

Guidance literature:: Multi-step reaction with 3 steps

1.1: dimethylsulfide borane complex / tetrahydrofuran / 2.5 h / 0 - 25 °C

2.1: triphenylphosphine; di-tert-butyl-diazodicarboxylate / dichloromethane; tetrahydrofuran / 20 °C

3.1: trifluoroacetic acid / 20 °C

3.2: 0.58 h / 150 °C / Microwave irradiation

With di-tert-butyl-diazodicarboxylate; dimethylsulfide borane complex; triphenylphosphine; trifluoroacetic acid; In tetrahydrofuran; dichloromethane;

Reference yield:

: 190957-22-3
(4R,1'R)-1-(1'-phenylethyl)-4-hydroxymethylpyrrolidin-2-one

: 1319737-92-2
(R)-4-((7-(4-hydroxy-3-methoxyphenyl)-1,6-naphthyridine-5-yloxy)methyl)pyrrolidine-2-one

Guidance literature:: Multi-step reaction with 2 steps

1.1: triphenylphosphine; di-tert-butyl-diazodicarboxylate / dichloromethane; tetrahydrofuran / 20 °C

2.1: trifluoroacetic acid / 20 °C

2.2: 0.58 h / 150 °C / Microwave irradiation

With di-tert-butyl-diazodicarboxylate; triphenylphosphine; trifluoroacetic acid; In tetrahydrofuran; dichloromethane;