methyl (S)-2-[(tert-butoxycarbonyl)amino]-3-[3-[(S)-2-[(tert-butoxycarbonyl)amino]-3-methoxy-3-oxopropyl]phenyl]propanoate

Base Information

• Chemical Name: methyl (S)-2-[(tert-butoxycarbonyl)amino]-3-[3-[(S)-2-[(tert-butoxycarbonyl)amino]-3-methoxy-3-oxopropyl]phenyl]propanoate
• CAS No.: 196860-98-7
• Molecular Formula: C₂₄H₃₆N₂O₈
• Molecular Weight: 480.558
• Mol file: 196860-98-7.mol

Synonyms:methyl (S)-2-[(tert-butoxycarbonyl)amino]-3-[3-[(S)-2-[(tert-butoxycarbonyl)amino]-3-methoxy-3-oxopropyl]phenyl]propanoate

Chemical Property of methyl (S)-2-[(tert-butoxycarbonyl)amino]-3-[3-[(S)-2-[(tert-butoxycarbonyl)amino]-3-methoxy-3-oxopropyl]phenyl]propanoate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of methyl (S)-2-[(tert-butoxycarbonyl)amino]-3-[3-[(S)-2-[(tert-butoxycarbonyl)amino]-3-methoxy-3-oxopropyl]phenyl]propanoate

There total 10 articles about methyl (S)-2-[(tert-butoxycarbonyl)amino]-3-[3-[(S)-2-[(tert-butoxycarbonyl)amino]-3-methoxy-3-oxopropyl]phenyl]propanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

di-tert-butyl dicarbonate (24424-99-5) + methyl (S)-2-[[(benzyloxy)carbonyl]amino]-3-[3-[(S)-2-[(tert-butoxycarbonyl)amino]-3-methoxy-3-oxopropyl]phenyl]propanoate (196860-97-6) → methyl (S)-2-[(tert-butoxycarbonyl)amino]-3-[3-[(S)-2-[(tert-butoxycarbonyl)amino]-3-methoxy-3-oxopropyl]phenyl]propanoate (196860-98-7)

Guidance literature:

With dmap; hydrogen; palladium on activated charcoal; In methanol; for 10h;

DOI:10.1021/jo971077h

Reference yield:

Isophthalaldehyde (626-19-7) → methyl (S)-2-[(tert-butoxycarbonyl)amino]-3-[3-[(S)-2-[(tert-butoxycarbonyl)amino]-3-methoxy-3-oxopropyl]phenyl]propanoate (196860-98-7)

Guidance literature:

Multi-step reaction with 6 steps

1.1: tetramethylguanidine / CH₂Cl₂ / 0.5 h

1.2: 94 percent / CH₂Cl₂ / 0.17 h

2.1: tetramethylguanidine / CH₂Cl₂ / 0.5 h / 20 °C

2.2: 83 percent / CH₂Cl₂ / 24 h

3.1: 96 percent / H₂ / rhodium 2(S),5(S)-dimethyl-1,2-bisphospholanobenzene / methanol / 12 h / 2327.17 - 2585.74 Torr

4.1: 97 percent / water; Bu₄NF / dimethylformamide / 12 h / 0 °C

5.1: 84 percent / CHCl₃; methanol; hexane

6.1: 100 percent / H₂; DMAP / Pd/C / methanol / 10 h

With dmap; 1,1,3,3-tetramethylguanidine; tetrabutyl ammonium fluoride; water; hydrogen; palladium on activated charcoal; rhodium 2(S),5(S)-dimethyl-1,2-bisphospholanobenzene; In methanol; hexane; dichloromethane; chloroform; N,N-dimethyl-formamide; 1.1: deprotonation / 1.2: Horner-Wittig coupling / 2.1: deprotonation / 2.2: Horner-Wittig coupling / 3.1: Catalytic hydrogenation / 4.1: Hydrolysis / 5.1: Esterification / 6.1: Hydrogenolysis;

DOI:10.1021/jo971077h

Reference yield:

di-tert-butyl dicarbonate (24424-99-5) → methyl (S)-2-[(tert-butoxycarbonyl)amino]-3-[3-[(S)-2-[(tert-butoxycarbonyl)amino]-3-methoxy-3-oxopropyl]phenyl]propanoate (196860-98-7)

Guidance literature:

Multi-step reaction with 8 steps

1.1: CH₂Cl₂

2.1: 74 percent / aq. NaOH / dioxane / 1.25 h / 0 °C

3.1: 98 percent / DCC / CH₂Cl₂ / 8 h / 0 °C

4.1: tetramethylguanidine / CH₂Cl₂ / 0.5 h / 20 °C

4.2: 83 percent / CH₂Cl₂ / 24 h

5.1: 96 percent / H₂ / rhodium 2(S),5(S)-dimethyl-1,2-bisphospholanobenzene / methanol / 12 h / 2327.17 - 2585.74 Torr

6.1: 97 percent / water; Bu₄NF / dimethylformamide / 12 h / 0 °C

7.1: 84 percent / CHCl₃; methanol; hexane

8.1: 100 percent / H₂; DMAP / Pd/C / methanol / 10 h

With dmap; sodium hydroxide; 1,1,3,3-tetramethylguanidine; tetrabutyl ammonium fluoride; water; hydrogen; dicyclohexyl-carbodiimide; palladium on activated charcoal; rhodium 2(S),5(S)-dimethyl-1,2-bisphospholanobenzene; In 1,4-dioxane; methanol; hexane; dichloromethane; chloroform; N,N-dimethyl-formamide; 1.1: Acylation / 2.1: Hydrolysis / 3.1: Esterification / 4.1: deprotonation / 4.2: Horner-Wittig coupling / 5.1: Catalytic hydrogenation / 6.1: Hydrolysis / 7.1: Esterification / 8.1: Hydrogenolysis;

DOI:10.1021/jo971077h

upstream raw materials:

di-tert-butyl dicarbonate

methyl (S)-2-[[(benzyloxy)carbonyl]amino]-3-[3-[(S)-2-[(tert-butoxycarbonyl)amino]-3-methoxy-3-oxopropyl]phenyl]propanoate

Isophthalaldehyde

(±)-2-((tert-butoxycarbonyl)amino)-2-(dimethoxyphosphoryl)acetic acid

Downstream raw materials:

α-methyl N-(tert-butoxycarbonyl)aspartate