1-(2-((4-(2-methyl-5-(m-tolyl)oxazole-4-carboxamido)-2H-1,2,3-triazol-2-yl)methyl)oxazol-4-yI)cyclopropyl pivalate

Base Information

• Chemical Name: 1-(2-((4-(2-methyl-5-(m-tolyl)oxazole-4-carboxamido)-2H-1,2,3-triazol-2-yl)methyl)oxazol-4-yI)cyclopropyl pivalate
• CAS No.: 1380666-02-3
• Molecular Formula: C₂₆H₂₈N₆O₅
• Molecular Weight: 504.546

Synonyms:1-(2-((4-(2-methyl-5-(m-tolyl)oxazole-4-carboxamido)-2H-1,2,3-triazol-2-yl)methyl)oxazol-4-yI)cyclopropyl pivalate

Chemical Property of 1-(2-((4-(2-methyl-5-(m-tolyl)oxazole-4-carboxamido)-2H-1,2,3-triazol-2-yl)methyl)oxazol-4-yI)cyclopropyl pivalate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 1-(2-((4-(2-methyl-5-(m-tolyl)oxazole-4-carboxamido)-2H-1,2,3-triazol-2-yl)methyl)oxazol-4-yI)cyclopropyl pivalate

There total 10 articles about 1-(2-((4-(2-methyl-5-(m-tolyl)oxazole-4-carboxamido)-2H-1,2,3-triazol-2-yl)methyl)oxazol-4-yI)cyclopropyl pivalate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2-methyl-5-(m-tolyl)oxazole-4-carboxylic acid (1007873-66-6) + 1-(2-((4-amino-2H-1,2,3-triazol-2-yl)methyl)oxazol-4-yl)cyclopropyl pivalate (1380666-01-2) → 1-(2-((4-(2-methyl-5-(m-tolyl)oxazole-4-carboxamido)-2H-1,2,3-triazol-2-yl)methyl)oxazol-4-yI)cyclopropyl pivalate (1380666-02-3)

Guidance literature:

2-methyl-5-(m-tolyl)oxazole-4-carboxylic acid; With ethylene dichloride hydrochloride; benzotriazol-1-ol; N-ethyl-N,N-diisopropylamine; dmap; In dichloromethane; at 20 ℃; for 0.5h; Inert atmosphere;

1-(2-((4-amino-2H-1,2,3-triazol-2-yl)methyl)oxazol-4-yl)cyclopropyl pivalate; In dichloromethane; at 20 ℃;

Reference yield:

methyl 2-(chloromethyl)-1,3-oxazole-4-carboxylate (208465-72-9) → 1-(2-((4-(2-methyl-5-(m-tolyl)oxazole-4-carboxamido)-2H-1,2,3-triazol-2-yl)methyl)oxazol-4-yI)cyclopropyl pivalate (1380666-02-3)

Guidance literature:

Multi-step reaction with 10 steps

1.1: sodium acetate / acetic acid / 3 h / 120 °C / Inert atmosphere

2.1: sodium; methanol / 1 h / 20 °C / Inert atmosphere

3.1: 1H-imidazole / tetrahydrofuran / 2.5 h / 20 °C / Inert atmosphere

4.1: titanium(IV)isopropoxide / tetrahydrofuran / 3.5 h / 20 °C / Inert atmosphere

5.1: pyridine / 20 °C / Inert atmosphere

6.1: tetrabutyl ammonium fluoride / tetrahydrofuran / 0.5 h / 0 °C / Inert atmosphere

7.1: triethylamine / dmap / dichloromethane / 1 h / 0 - 20 °C / Inert atmosphere

8.1: N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 50 °C / Inert atmosphere

9.1: ammonium chloride; iron / ethanol; water / 0.25 h / 85 °C / Inert atmosphere

10.1: N-ethyl-N,N-diisopropylamine; benzotriazol-1-ol; ethylene dichloride hydrochloride / dmap / dichloromethane / 0.5 h / 20 °C / Inert atmosphere

10.2: 20 °C

With 1H-imidazole; methanol; ethylene dichloride hydrochloride; tetrabutyl ammonium fluoride; sodium acetate; sodium; iron; ammonium chloride; benzotriazol-1-ol; triethylamine; N-ethyl-N,N-diisopropylamine; dmap; titanium(IV)isopropoxide; In tetrahydrofuran; pyridine; ethanol; dichloromethane; water; acetic acid; N,N-dimethyl-formamide;

Reference yield:

methyl 2-(acetoxymethyl)oxazole-4-carboxylate (1227245-51-3) → 1-(2-((4-(2-methyl-5-(m-tolyl)oxazole-4-carboxamido)-2H-1,2,3-triazol-2-yl)methyl)oxazol-4-yI)cyclopropyl pivalate (1380666-02-3)

Guidance literature:

Multi-step reaction with 9 steps

1.1: sodium; methanol / 1 h / 20 °C / Inert atmosphere

2.1: 1H-imidazole / tetrahydrofuran / 2.5 h / 20 °C / Inert atmosphere

3.1: titanium(IV)isopropoxide / tetrahydrofuran / 3.5 h / 20 °C / Inert atmosphere

4.1: pyridine / 20 °C / Inert atmosphere

5.1: tetrabutyl ammonium fluoride / tetrahydrofuran / 0.5 h / 0 °C / Inert atmosphere

6.1: triethylamine / dmap / dichloromethane / 1 h / 0 - 20 °C / Inert atmosphere

7.1: N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 50 °C / Inert atmosphere

8.1: ammonium chloride; iron / ethanol; water / 0.25 h / 85 °C / Inert atmosphere

9.1: N-ethyl-N,N-diisopropylamine; benzotriazol-1-ol; ethylene dichloride hydrochloride / dmap / dichloromethane / 0.5 h / 20 °C / Inert atmosphere

9.2: 20 °C

With 1H-imidazole; methanol; ethylene dichloride hydrochloride; tetrabutyl ammonium fluoride; sodium; iron; ammonium chloride; benzotriazol-1-ol; triethylamine; N-ethyl-N,N-diisopropylamine; dmap; titanium(IV)isopropoxide; In tetrahydrofuran; pyridine; ethanol; dichloromethane; water; N,N-dimethyl-formamide;

upstream raw materials:

methyl 2-(chloromethyl)-1,3-oxazole-4-carboxylate

2-methyl-5-(m-tolyl)oxazole-4-carboxylic acid

1-(2-((4-amino-2H-1,2,3-triazol-2-yl)methyl)oxazol-4-yl)cyclopropyl pivalate

methyl 2-(acetoxymethyl)oxazole-4-carboxylate

Downstream raw materials:

2-methyl-5-m-tolyl-oxazole-4-carboxylic acid {2-[4-(1-hydroxy-cyclopropyl)-oxazol-2-ylmethyl]-2H-[1,2,3]triazol-4-yl}-amide

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