7-[2-((Z)-3-ethylaminoprop-1-enyl)-4-fluorobenzenesulfonylamino]-4H-furo[2,3-c]chromene-6-carboxlic acid

Base Information

Chemical Name:7-[2-((Z)-3-ethylaminoprop-1-enyl)-4-fluorobenzenesulfonylamino]-4H-furo[2,3-c]chromene-6-carboxlic acid
CAS No.:1356111-00-6
Molecular Formula:C₂₃H₂₁FN₂O₆S
Molecular Weight:472.494
Hs Code.:

Synonyms:7-[2-((Z)-3-ethylaminoprop-1-enyl)-4-fluorobenzenesulfonylamino]-4H-furo[2,3-c]chromene-6-carboxlic acid

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Chemical Property of 7-[2-((Z)-3-ethylaminoprop-1-enyl)-4-fluorobenzenesulfonylamino]-4H-furo[2,3-c]chromene-6-carboxlic acid

Chemical Property:

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Technology Process of 7-[2-((Z)-3-ethylaminoprop-1-enyl)-4-fluorobenzenesulfonylamino]-4H-furo[2,3-c]chromene-6-carboxlic acid

There total 12 articles about 7-[2-((Z)-3-ethylaminoprop-1-enyl)-4-fluorobenzenesulfonylamino]-4H-furo[2,3-c]chromene-6-carboxlic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1356112-58-7
methyl 7-[2-((Z)-3-ethylaminoprop-1-enyl)-4-fluorobenzenesulfonylamino]-4H-furo[2,3-c]chromene-6-carboxylate

: 1356111-00-6
7-[2-((Z)-3-ethylaminoprop-1-enyl)-4-fluorobenzenesulfonylamino]-4H-furo[2,3-c]chromene-6-carboxlic acid

Guidance literature:: With lithium hydroxide monohydrate; water; In 1,4-dioxane; at 135 ℃; for 0.75h; Microwave irradiation; Sealed vial;

Reference yield:

: 681247-11-0
methyl 6-amino-3-bromo-2-hydroxybenzoate

: 1356111-00-6
7-[2-((Z)-3-ethylaminoprop-1-enyl)-4-fluorobenzenesulfonylamino]-4H-furo[2,3-c]chromene-6-carboxlic acid

Guidance literature:: Multi-step reaction with 11 steps

1.1: caesium carbonate; tri tert-butylphosphoniumtetrafluoroborate / tris-(dibenzylideneacetone)dipalladium⁽⁰⁾ / 1,4-dioxane; water / 1 h / 65 °C / Inert atmosphere

2.1: dmap; triethylamine / dichloromethane / 1 h

2.2: 2 h

3.1: ethanol; sodium tetrahydroborate / 0.25 h

4.1: sodium hydroxide; water / methanol / 1.5 h / 45 °C

5.1: carbon tetrabromide; triphenylphosphine / dichloromethane / 1 h / 20 °C

5.2: 1 h

6.1: hydrogenchloride / 1,4-dioxane / 1.5 h

6.2: 18 h

7.1: sodium hydride / tetrahydrofuran; mineral oil / 0.08 h / 20 °C

7.2: 1 h / 20 °C

8.1: tri tert-butylphosphoniumtetrafluoroborate / tris-(dibenzylideneacetone)dipalladium⁽⁰⁾ / 1,4-dioxane; dimethyl sulfoxide / 0.75 h / 95 °C / Inert atmosphere

9.1: N-ethyl-N,N-diisopropylamine; methanesulfonyl chloride / dichloromethane / 0.5 h / Cooling with ice

9.2: 5 h / 20 °C

10.1: trifluoroacetic acid / dichloromethane / 0.5 h / 20 °C

11.1: water; lithium hydroxide monohydrate / 1,4-dioxane / 0.75 h / 135 °C / Microwave irradiation; Sealed vial

With hydrogenchloride; dmap; sodium tetrahydroborate; lithium hydroxide monohydrate; ethanol; carbon tetrabromide; water; sodium hydride; caesium carbonate; methanesulfonyl chloride; triethylamine; N-ethyl-N,N-diisopropylamine; triphenylphosphine; trifluoroacetic acid; sodium hydroxide; tri tert-butylphosphoniumtetrafluoroborate; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; In tetrahydrofuran; 1,4-dioxane; methanol; dichloromethane; water; dimethyl sulfoxide; mineral oil;

Reference yield:

: 1055881-23-6
3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)furan-2-carbaldehyde

: 1356111-00-6
7-[2-((Z)-3-ethylaminoprop-1-enyl)-4-fluorobenzenesulfonylamino]-4H-furo[2,3-c]chromene-6-carboxlic acid

Guidance literature:: Multi-step reaction with 11 steps

1.1: caesium carbonate; tri tert-butylphosphoniumtetrafluoroborate / tris-(dibenzylideneacetone)dipalladium⁽⁰⁾ / 1,4-dioxane; water / 1 h / 65 °C / Inert atmosphere

2.1: dmap; triethylamine / dichloromethane / 1 h

2.2: 2 h

3.1: ethanol; sodium tetrahydroborate / 0.25 h

4.1: sodium hydroxide; water / methanol / 1.5 h / 45 °C

5.1: carbon tetrabromide; triphenylphosphine / dichloromethane / 1 h / 20 °C

5.2: 1 h

6.1: hydrogenchloride / 1,4-dioxane / 1.5 h

6.2: 18 h

7.1: sodium hydride / tetrahydrofuran; mineral oil / 0.08 h / 20 °C

7.2: 1 h / 20 °C

8.1: tri tert-butylphosphoniumtetrafluoroborate / tris-(dibenzylideneacetone)dipalladium⁽⁰⁾ / 1,4-dioxane; dimethyl sulfoxide / 0.75 h / 95 °C / Inert atmosphere

9.1: N-ethyl-N,N-diisopropylamine; methanesulfonyl chloride / dichloromethane / 0.5 h / Cooling with ice

9.2: 5 h / 20 °C

10.1: trifluoroacetic acid / dichloromethane / 0.5 h / 20 °C

11.1: water; lithium hydroxide monohydrate / 1,4-dioxane / 0.75 h / 135 °C / Microwave irradiation; Sealed vial

With hydrogenchloride; dmap; sodium tetrahydroborate; lithium hydroxide monohydrate; ethanol; carbon tetrabromide; water; sodium hydride; caesium carbonate; methanesulfonyl chloride; triethylamine; N-ethyl-N,N-diisopropylamine; triphenylphosphine; trifluoroacetic acid; sodium hydroxide; tri tert-butylphosphoniumtetrafluoroborate; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; In tetrahydrofuran; 1,4-dioxane; methanol; dichloromethane; water; dimethyl sulfoxide; mineral oil;