5-[2-ethoxy-5-(piperidin-1-ylsulfonyl)phenyl]-1,3-dimethyl-1H-pyrazolo[4,3-e][1,2,4]triazine

Base Information

• Chemical Name: 5-[2-ethoxy-5-(piperidin-1-ylsulfonyl)phenyl]-1,3-dimethyl-1H-pyrazolo[4,3-e][1,2,4]triazine
• CAS No.: 1607820-52-9
• Molecular Formula: C₁₉H₂₄N₆O₃S
• Molecular Weight: 416.504

Synonyms:5-[2-ethoxy-5-(piperidin-1-ylsulfonyl)phenyl]-1,3-dimethyl-1H-pyrazolo[4,3-e][1,2,4]triazine

Chemical Property of 5-[2-ethoxy-5-(piperidin-1-ylsulfonyl)phenyl]-1,3-dimethyl-1H-pyrazolo[4,3-e][1,2,4]triazine

Chemical Property:

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Technology Process of 5-[2-ethoxy-5-(piperidin-1-ylsulfonyl)phenyl]-1,3-dimethyl-1H-pyrazolo[4,3-e][1,2,4]triazine

There total 10 articles about 5-[2-ethoxy-5-(piperidin-1-ylsulfonyl)phenyl]-1,3-dimethyl-1H-pyrazolo[4,3-e][1,2,4]triazine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

piperidine (110-89-4) + 4-ethoxy-3-(1,3-dimethyl-1H-pyrazolo[4,3-e][1,2,4]-triazin-5-yl)benzene-1-sulfonyl chloride (1607820-48-3) → 5-[2-ethoxy-5-(piperidin-1-ylsulfonyl)phenyl]-1,3-dimethyl-1H-pyrazolo[4,3-e][1,2,4]triazine (1607820-52-9)

Guidance literature:

In acetonitrile; at 20 ℃;

DOI:10.1016/j.bmc.2014.10.009

Reference yield:

(2-ethoxyphenyl)boronic acid (213211-69-9) → 5-[2-ethoxy-5-(piperidin-1-ylsulfonyl)phenyl]-1,3-dimethyl-1H-pyrazolo[4,3-e][1,2,4]triazine (1607820-52-9)

Guidance literature:

Multi-step reaction with 3 steps

1: tetrakis(triphenylphosphine) palladium⁽⁰⁾; copper(I) 2-hydroxy-3-methylbenzoate / tetrahydrofuran / Inert atmosphere; Reflux

2: chlorosulfonic acid / 2 h / 0 - 20 °C

3: acetonitrile / 20 °C

With chlorosulfonic acid; tetrakis(triphenylphosphine) palladium⁽⁰⁾; copper(I) 2-hydroxy-3-methylbenzoate; In tetrahydrofuran; acetonitrile;

DOI:10.1016/j.bmc.2014.03.029

Reference yield:

1,3-dimethyl-5-(methylsulfanyl)-1H-pyrazolo[4,3-e][1,2,4]triazine (682319-80-8) → 5-[2-ethoxy-5-(piperidin-1-ylsulfonyl)phenyl]-1,3-dimethyl-1H-pyrazolo[4,3-e][1,2,4]triazine (1607820-52-9)

Guidance literature:

Multi-step reaction with 3 steps

1: tetrakis(triphenylphosphine) palladium⁽⁰⁾; copper(I) 2-hydroxy-3-methylbenzoate / tetrahydrofuran / Inert atmosphere; Reflux

2: chlorosulfonic acid / 2 h / 0 - 20 °C

3: acetonitrile / 20 °C

With chlorosulfonic acid; tetrakis(triphenylphosphine) palladium⁽⁰⁾; copper(I) 2-hydroxy-3-methylbenzoate; In tetrahydrofuran; acetonitrile;

DOI:10.1016/j.bmc.2014.03.029

upstream raw materials:

1,3-dimethyl-5-(methylsulfanyl)-1H-pyrazolo[4,3-e][1,2,4]triazine

(2-ethoxyphenyl)boronic acid

3-(2-ethoxyphenyl)-1,3-dimethyl-1H-pyrazolo[4,3-e][1,2,4]-triazine

piperidine

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