6-Amino-5-phenyl-hexanoic acid 2,5-dioxo-pyrrolidin-1-yl ester; hydrochloride

Base Information

Chemical Name:6-Amino-5-phenyl-hexanoic acid 2,5-dioxo-pyrrolidin-1-yl ester; hydrochloride
CAS No.:111742-91-7
Molecular Formula:C₁₆H₂₀N₂O₄*ClH
Molecular Weight:340.807
Hs Code.:

Synonyms:6-Amino-5-phenyl-hexanoic acid 2,5-dioxo-pyrrolidin-1-yl ester; hydrochloride

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Chemical Property of 6-Amino-5-phenyl-hexanoic acid 2,5-dioxo-pyrrolidin-1-yl ester; hydrochloride

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Technology Process of 6-Amino-5-phenyl-hexanoic acid 2,5-dioxo-pyrrolidin-1-yl ester; hydrochloride

There total 6 articles about 6-Amino-5-phenyl-hexanoic acid 2,5-dioxo-pyrrolidin-1-yl ester; hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

: 111742-90-6
6-tert-Butoxycarbonylamino-5-phenyl-hexanoic acid 2,5-dioxo-pyrrolidin-1-yl ester

: 111742-91-7
6-Amino-5-phenyl-hexanoic acid 2,5-dioxo-pyrrolidin-1-yl ester; hydrochloride

Guidance literature:: With hydrogenchloride; In 1,4-dioxane; for 1.5h; Ambient temperature;
DOI:10.1021/jm00397a027

Reference yield:

: 140-29-4
phenylacetonitrile

: 111742-91-7
6-Amino-5-phenyl-hexanoic acid 2,5-dioxo-pyrrolidin-1-yl ester; hydrochloride

Guidance literature:: Multi-step reaction with 6 steps

1: 58 percent / NaH / dimethylformamide; paraffin / 4 h / Ambient temperature

2: H₂ / Raney-Ni / ethanol / 2.5 h / 40 °C

3: 30 percent / Et₃N / CH₂Cl₂ / 1 h / Ambient temperature

4: aq. NaOH / ethanol / 1 h / Ambient temperature

5: 87 percent / DCC / CH₂Cl₂ / Ambient temperature

6: 95 percent / 4N HCl / dioxane / 1.5 h / Ambient temperature

With hydrogenchloride; sodium hydroxide; hydrogen; sodium hydride; triethylamine; dicyclohexyl-carbodiimide; nickel; In 1,4-dioxane; ethanol; dichloromethane; N,N-dimethyl-formamide; paraffin;
DOI:10.1021/jm00397a027

Reference yield:

: 112093-40-0
Phenyl-5 cyano-5 pentanoate d'ethyle

: 111742-91-7
6-Amino-5-phenyl-hexanoic acid 2,5-dioxo-pyrrolidin-1-yl ester; hydrochloride

Guidance literature:: Multi-step reaction with 5 steps

1: H₂ / Raney-Ni / ethanol / 2.5 h / 40 °C

2: 30 percent / Et₃N / CH₂Cl₂ / 1 h / Ambient temperature

3: aq. NaOH / ethanol / 1 h / Ambient temperature

4: 87 percent / DCC / CH₂Cl₂ / Ambient temperature

5: 95 percent / 4N HCl / dioxane / 1.5 h / Ambient temperature

With hydrogenchloride; sodium hydroxide; hydrogen; triethylamine; dicyclohexyl-carbodiimide; nickel; In 1,4-dioxane; ethanol; dichloromethane;
DOI:10.1021/jm00397a027