N-[3-[2-[4-(2-methoxyphenyl)piperazin-1-yl]ethyl]-2,4-dioxo-1,2,3,4-tetrahydro[1]benzothieno[3,2-d]pyrimidin-8-yl]-4-phenylbutanamide

Base Information

• Chemical Name: N-[3-[2-[4-(2-methoxyphenyl)piperazin-1-yl]ethyl]-2,4-dioxo-1,2,3,4-tetrahydro[1]benzothieno[3,2-d]pyrimidin-8-yl]-4-phenylbutanamide
• CAS No.: 1621317-82-5
• Molecular Formula: C₃₃H₃₅N₅O₄S
• Molecular Weight: 597.738

Synonyms:N-[3-[2-[4-(2-methoxyphenyl)piperazin-1-yl]ethyl]-2,4-dioxo-1,2,3,4-tetrahydro[1]benzothieno[3,2-d]pyrimidin-8-yl]-4-phenylbutanamide

Chemical Property of N-[3-[2-[4-(2-methoxyphenyl)piperazin-1-yl]ethyl]-2,4-dioxo-1,2,3,4-tetrahydro[1]benzothieno[3,2-d]pyrimidin-8-yl]-4-phenylbutanamide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
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Technology Process of N-[3-[2-[4-(2-methoxyphenyl)piperazin-1-yl]ethyl]-2,4-dioxo-1,2,3,4-tetrahydro[1]benzothieno[3,2-d]pyrimidin-8-yl]-4-phenylbutanamide

There total 7 articles about N-[3-[2-[4-(2-methoxyphenyl)piperazin-1-yl]ethyl]-2,4-dioxo-1,2,3,4-tetrahydro[1]benzothieno[3,2-d]pyrimidin-8-yl]-4-phenylbutanamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 59.0%

8-amino-3-[2-[4-(2-methoxyphenyl)-1-piperazinyl]ethyl][1]benzothieno[3,2-d]pyrimidine-2,4(1H,3H)-dione (1621317-76-7) + phenylbutyric acid chloride (18496-54-3) → N-[3-[2-[4-(2-methoxyphenyl)piperazin-1-yl]ethyl]-2,4-dioxo-1,2,3,4-tetrahydro[1]benzothieno[3,2-d]pyrimidin-8-yl]-4-phenylbutanamide (1621317-82-5)

Guidance literature:

With potassium carbonate; In tetrahydrofuran; at 20 ℃; for 6h;

DOI:10.1016/j.ejmech.2014.06.057

Reference yield:

C12H8ClN3O4S (1621317-72-3) → N-[3-[2-[4-(2-methoxyphenyl)piperazin-1-yl]ethyl]-2,4-dioxo-1,2,3,4-tetrahydro[1]benzothieno[3,2-d]pyrimidin-8-yl]-4-phenylbutanamide (1621317-82-5)

Guidance literature:

Multi-step reaction with 3 steps

1: 0.5 h / 160 °C

2: hydrazine hydrate / N,N-dimethyl-formamide / 24 h / 20 °C

3: potassium carbonate / tetrahydrofuran / 6 h / 20 °C

With potassium carbonate; hydrazine hydrate; In tetrahydrofuran; N,N-dimethyl-formamide;

DOI:10.1016/j.ejmech.2014.06.057

Reference yield:

ethyl (3-amino-5-nitrobenzothiophen)-2-carboxylate (27697-60-5) → N-[3-[2-[4-(2-methoxyphenyl)piperazin-1-yl]ethyl]-2,4-dioxo-1,2,3,4-tetrahydro[1]benzothieno[3,2-d]pyrimidin-8-yl]-4-phenylbutanamide (1621317-82-5)

Guidance literature:

Multi-step reaction with 6 steps

1: toluene / 26 h / 20 °C / Reflux

2: 0.67 h / 50 °C

3: thionyl chloride / toluene / 22 h / 20 °C / Reflux

4: 0.5 h / 160 °C

5: hydrazine hydrate / N,N-dimethyl-formamide / 24 h / 20 °C

6: potassium carbonate / tetrahydrofuran / 6 h / 20 °C

With thionyl chloride; potassium carbonate; hydrazine hydrate; In tetrahydrofuran; N,N-dimethyl-formamide; toluene;

DOI:10.1016/j.ejmech.2014.06.057

upstream raw materials:

C₁₂H₈ClN₃O₄S

ethyl (3-amino-5-nitrobenzothiophen)-2-carboxylate

ethyl 3-[(ethoxycarbonyl)amino]-5-nitro-1-benzothiophene-2-carboxylate

3-(2-hydroxyethyl)-8-nitro[1]benzothieno[3,2-d]pyrimidine-2,4(1H,3H)-dione

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