2,2-Dimethyl-propionic acid (1R,2R)-2-(benzhydryl-amino)-3-(tert-butyl-dimethyl-silanyloxy)-1-((S)-1,2-dihydroxy-ethyl)-propyl ester

Base Information

Chemical Name:2,2-Dimethyl-propionic acid (1R,2R)-2-(benzhydryl-amino)-3-(tert-butyl-dimethyl-silanyloxy)-1-((S)-1,2-dihydroxy-ethyl)-propyl ester
CAS No.:1053370-76-5
Molecular Formula:C₂₉H₄₅NO₅Si
Molecular Weight:515.765
Hs Code.:

Synonyms:2,2-Dimethyl-propionic acid (1R,2R)-2-(benzhydryl-amino)-3-(tert-butyl-dimethyl-silanyloxy)-1-((S)-1,2-dihydroxy-ethyl)-propyl ester

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Chemical Property of 2,2-Dimethyl-propionic acid (1R,2R)-2-(benzhydryl-amino)-3-(tert-butyl-dimethyl-silanyloxy)-1-((S)-1,2-dihydroxy-ethyl)-propyl ester

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Technology Process of 2,2-Dimethyl-propionic acid (1R,2R)-2-(benzhydryl-amino)-3-(tert-butyl-dimethyl-silanyloxy)-1-((S)-1,2-dihydroxy-ethyl)-propyl ester

There total 1 articles about 2,2-Dimethyl-propionic acid (1R,2R)-2-(benzhydryl-amino)-3-(tert-butyl-dimethyl-silanyloxy)-1-((S)-1,2-dihydroxy-ethyl)-propyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 76.0%

: 301523-24-0
(4R,5R,6S)-4-(tert-butyldimethylsiloxymethyl)-6-hydroxymethyl-5-trimethylacetoxy-2,2-diphenyltetrahydro-1,3-oxazine

: 1053370-76-5
2,2-Dimethyl-propionic acid (1R,2R)-2-(benzhydryl-amino)-3-(tert-butyl-dimethyl-silanyloxy)-1-((S)-1,2-dihydroxy-ethyl)-propyl ester

Guidance literature:: With 4 A molecular sieve; sodium cyanoborohydride; acetic acid; In acetonitrile;
DOI:10.1021/jo000527u

Reference yield:

: 1053370-76-5
2,2-Dimethyl-propionic acid (1R,2R)-2-(benzhydryl-amino)-3-(tert-butyl-dimethyl-silanyloxy)-1-((S)-1,2-dihydroxy-ethyl)-propyl ester

: 301523-26-2
5-O-tert-butyldimethylsilyl-N-diphenylmethyl-1,4-dideoxy-1,4-imino-D-ribitol

Guidance literature:: 2,2-Dimethyl-propionic acid (1R,2R)-2-(benzhydryl-amino)-3-(tert-butyl-dimethyl-silanyloxy)-1-((S)-1,2-dihydroxy-ethyl)-propyl ester; With tetrachloromethane; triethylamine; triphenylphosphine; In N,N-dimethyl-formamide; at 20 ℃;

With sodium methylate; In methanol; Further stages.;
DOI:10.1021/jo000527u

Reference yield:

: 1053370-76-5
2,2-Dimethyl-propionic acid (1R,2R)-2-(benzhydryl-amino)-3-(tert-butyl-dimethyl-silanyloxy)-1-((S)-1,2-dihydroxy-ethyl)-propyl ester

: 2,2-Dimethyl-propionic acid (3S,4R,5R)-1-benzhydryl-5-(tert-butyl-dimethyl-silanyloxymethyl)-4-hydroxy-pyrrolidin-3-yl ester

: 2,2-Dimethyl-propionic acid (2R,3R,4S)-1-benzhydryl-2-(tert-butyl-dimethyl-silanyloxymethyl)-4-hydroxy-pyrrolidin-3-yl ester

Guidance literature:: With tetrachloromethane; triethylamine; triphenylphosphine; In N,N-dimethyl-formamide; at 20 ℃; Title compound not separated from byproducts.;
DOI:10.1021/jo000527u