methyl 6-(4'-tert-butyIbiphenyl-2-ylcarboxamido)benzo[d]thiazole-2-carboxylate

Base Information

• Chemical Name: methyl 6-(4'-tert-butyIbiphenyl-2-ylcarboxamido)benzo[d]thiazole-2-carboxylate
• CAS No.: 1048367-38-9
• Molecular Formula: C₂₆H₂₄N₂O₃S
• Molecular Weight: 444.554
• Mol file: 1048367-38-9.mol

Synonyms:methyl 6-(4'-tert-butyIbiphenyl-2-ylcarboxamido)benzo[d]thiazole-2-carboxylate

Chemical Property of methyl 6-(4'-tert-butyIbiphenyl-2-ylcarboxamido)benzo[d]thiazole-2-carboxylate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of methyl 6-(4'-tert-butyIbiphenyl-2-ylcarboxamido)benzo[d]thiazole-2-carboxylate

There total 2 articles about methyl 6-(4'-tert-butyIbiphenyl-2-ylcarboxamido)benzo[d]thiazole-2-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 41.0%

4′-(tert butyl)-[1,1′-biphenyl]-2-carboxylic acid (84392-26-7) + methyl 6-aminobenzo[d]thiazole-2-carboxylate (1048367-37-8) → methyl 6-(4'-tert-butyIbiphenyl-2-ylcarboxamido)benzo[d]thiazole-2-carboxylate (1048367-38-9)

Guidance literature:

With dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In dichloromethane; at 20 ℃; for 18h;

Reference yield:

methyl 6-aminobenzo[d]thiazole-2-carboxylate (1048367-37-8) + C17H17ClO → methyl 6-(4'-tert-butyIbiphenyl-2-ylcarboxamido)benzo[d]thiazole-2-carboxylate (1048367-38-9)

Guidance literature:

With triethylamine; In tetrahydrofuran; dichloromethane;

DOI:10.1016/j.bmcl.2009.01.044

Reference yield: 70.0%

methyl 6-(4'-tert-butyIbiphenyl-2-ylcarboxamido)benzo[d]thiazole-2-carboxylate (1048367-38-9) → 6-(4'-tert-butylbiphenyl-2-ylcarboxamido)benzo[d]thiazole-2-carboxylic acid (1048366-25-1)

Guidance literature:

methyl 6-(4'-tert-butyIbiphenyl-2-ylcarboxamido)benzo[d]thiazole-2-carboxylate; With lithium hydroxide; water; In tetrahydrofuran; methanol; at 40 - 50 ℃; for 18h;

With hydrogenchloride; In water; pH=3;

upstream raw materials:

4′-(tert butyl)-[1,1′-biphenyl]-2-carboxylic acid

methyl 6-aminobenzo[d]thiazole-2-carboxylate

Downstream raw materials:

6-(4'-tert-butylbiphenyl-2-ylcarboxamido)benzo[d]thiazole-2-carboxylic acid