5-amino-1,2-bis(o-aminophenoxy)ethane-N,N,N’,N’-tetraacetic acid tetramethyl ester

Base Information

• Chemical Name: 5-amino-1,2-bis(o-aminophenoxy)ethane-N,N,N’,N’-tetraacetic acid tetramethyl ester
• CAS No.: 172646-07-0
• Molecular Formula: C₂₆H₃₃N₃O₁₀
• Molecular Weight: 547.562
• Mol file: 172646-07-0.mol

Synonyms:5-amino-1,2-bis(o-aminophenoxy)ethane-N,N,N’,N’-tetraacetic acid tetramethyl ester

Chemical Property of 5-amino-1,2-bis(o-aminophenoxy)ethane-N,N,N’,N’-tetraacetic acid tetramethyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 5-amino-1,2-bis(o-aminophenoxy)ethane-N,N,N’,N’-tetraacetic acid tetramethyl ester

There total 2 articles about 5-amino-1,2-bis(o-aminophenoxy)ethane-N,N,N’,N’-tetraacetic acid tetramethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 53.0%

5-nitro-BAPTA-tetramethyl ester (172646-43-4) → 5-amino-1,2-bis(o-aminophenoxy)ethane-N,N,N’,N’-tetraacetic acid tetramethyl ester (172646-07-0)

Guidance literature:

With hydrogen; 5%-palladium/activated carbon; In ethanol; for 5h;

Reference yield:

1,2-bis(2-aminophenoxy)ethane-N,N,N',N'-tetraacetic acid tetrakis acetoxymethyl ester (125367-34-2) → 5-amino-1,2-bis(o-aminophenoxy)ethane-N,N,N’,N’-tetraacetic acid tetramethyl ester (172646-07-0)

Guidance literature:

Multi-step reaction with 2 steps

1: nitric acid / acetic acid / 0 °C

2: palladium on activated charcoal; hydrogen / methanol; dichloromethane / 20 °C

With palladium on activated charcoal; hydrogen; nitric acid; In methanol; dichloromethane; acetic acid;

DOI:10.1002/anie.201210279

Reference yield: 77.0%

formaldehyd (50-00-0,30525-89-4,61233-19-0) + 5-amino-1,2-bis(o-aminophenoxy)ethane-N,N,N’,N’-tetraacetic acid tetramethyl ester (172646-07-0) → N-methyl-5-amino-BAPTA tetramethyl ester

Guidance literature:

With palladium on activated charcoal; hydrogen; In water; ethyl acetate; at 20 ℃; for 39h;

DOI:10.1021/jacs.9b06092

upstream raw materials:

5-nitro-BAPTA-tetramethyl ester

1,2-bis(2-aminophenoxy)ethane-N,N,N',N'-tetraacetic acid tetrakis acetoxymethyl ester

Downstream raw materials:

C₄₁H₄₆N₄O₁₂

C₄₅H₄₃N₃O₁₃Si

C₄₅H₄₁Cl₂N₃O₁₃Si

Refernces

• 1、 -. "TWO-PHOTON PROBE FOR REAL-TIME MONITORING OF INTRACELLULAR CALCIUM IONS, METHOD FOR PREPARING THE PROBE AND METHOD FOR REAL-TIME MONITORING OF INTRACELLULAR CALCIUM IONS USING THE PROBE". Page/Page column 9-10. . Retrieved 2009/04/25.