(S)-benzyl 7-hydroxy-3-(phenethylcarbamoyl)-3,4-dihydroisoquinoline-2(1H)-carboxylate

Base Information

• Chemical Name: (S)-benzyl 7-hydroxy-3-(phenethylcarbamoyl)-3,4-dihydroisoquinoline-2(1H)-carboxylate
• CAS No.: 1223621-37-1
• Molecular Formula: C₂₆H₂₆N₂O₄
• Molecular Weight: 430.503
• Mol file: 1223621-37-1.mol

Synonyms:(S)-benzyl 7-hydroxy-3-(phenethylcarbamoyl)-3,4-dihydroisoquinoline-2(1H)-carboxylate

Chemical Property of (S)-benzyl 7-hydroxy-3-(phenethylcarbamoyl)-3,4-dihydroisoquinoline-2(1H)-carboxylate

Chemical Property:

Purity/Quality:

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Technology Process of (S)-benzyl 7-hydroxy-3-(phenethylcarbamoyl)-3,4-dihydroisoquinoline-2(1H)-carboxylate

There total 1 articles about (S)-benzyl 7-hydroxy-3-(phenethylcarbamoyl)-3,4-dihydroisoquinoline-2(1H)-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 67.0%

phenethylamine (64-04-0) + (3S)-N-benzyloxycarbonyl-1,2,3,4-tetrahydro-7-hydroxyisoquinoline-3-carboxylic acid (201413-65-2) → (S)-benzyl 7-hydroxy-3-(phenethylcarbamoyl)-3,4-dihydroisoquinoline-2(1H)-carboxylate (1223621-37-1)

Guidance literature:

(3S)-N-benzyloxycarbonyl-1,2,3,4-tetrahydro-7-hydroxyisoquinoline-3-carboxylic acid; With benzotriazol-1-ol; dicyclohexyl-carbodiimide; In tetrahydrofuran; at 0 ℃; for 0.5h; Inert atmosphere;

phenethylamine; In tetrahydrofuran; at 20 ℃; Inert atmosphere;

DOI:10.1016/j.bmc.2010.01.060

Reference yield: 37.0%

(S)-benzyl 7-hydroxy-3-(phenethylcarbamoyl)-3,4-dihydroisoquinoline-2(1H)-carboxylate (1223621-37-1) + bromoacetic acid methyl ester (96-32-2) → (S)-benzyl 7-(2-methoxy-2-oxoethoxy)-3-(phenethylcarbamoyl)-3,4-dihydroisoquinoline-2(1H)-carboxylate (1223621-40-6)

Guidance literature:

With potassium carbonate; In N,N-dimethyl-formamide; at 20 ℃; for 3h; Inert atmosphere;

DOI:10.1016/j.bmc.2010.01.060

upstream raw materials:

phenethylamine

(3S)-N-benzyloxycarbonyl-1,2,3,4-tetrahydro-7-hydroxyisoquinoline-3-carboxylic acid

Downstream raw materials:

(S)-benzyl 7-(2-methoxy-2-oxoethoxy)-3-(phenethylcarbamoyl)-3,4-dihydroisoquinoline-2(1H)-carboxylate