(1R,3aS,8aS)-5-[2-[(3S,5R)-3,5-Bis-(tert-butyl-dimethyl-silanyloxy)-2-methylene-cyclohex-(Z)-ylidene]-eth-(E)-ylidene]-1-((R)-1,5-dimethyl-5-trimethylsilanyloxy-hexyl)-8a-methyl-decahydro-azulene

Base Information

Chemical Name:(1R,3aS,8aS)-5-[2-[(3S,5R)-3,5-Bis-(tert-butyl-dimethyl-silanyloxy)-2-methylene-cyclohex-(Z)-ylidene]-eth-(E)-ylidene]-1-((R)-1,5-dimethyl-5-trimethylsilanyloxy-hexyl)-8a-methyl-decahydro-azulene
CAS No.:145459-14-9
Molecular Formula:C₄₃H₈₂O₃Si₃
Molecular Weight:731.379
Hs Code.:

(1R,3aS,8aS)-5-[2-[(3S,5R)-3,5-Bis-(tert-butyl-dimethyl-silanyloxy)-2-methylene-cyclohex-(Z)-ylidene]-eth-(E)-ylidene]-1-((R)-1,5-dimethyl-5-trimethylsilanyloxy-hexyl)-8a-methyl-decahydro-azulene

Synonyms:(1R,3aS,8aS)-5-[2-[(3S,5R)-3,5-Bis-(tert-butyl-dimethyl-silanyloxy)-2-methylene-cyclohex-(Z)-ylidene]-eth-(E)-ylidene]-1-((R)-1,5-dimethyl-5-trimethylsilanyloxy-hexyl)-8a-methyl-decahydro-azulene

Suppliers and Price of (1R,3aS,8aS)-5-[2-[(3S,5R)-3,5-Bis-(tert-butyl-dimethyl-silanyloxy)-2-methylene-cyclohex-(Z)-ylidene]-eth-(E)-ylidene]-1-((R)-1,5-dimethyl-5-trimethylsilanyloxy-hexyl)-8a-methyl-decahydro-azulene

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (1R,3aS,8aS)-5-[2-[(3S,5R)-3,5-Bis-(tert-butyl-dimethyl-silanyloxy)-2-methylene-cyclohex-(Z)-ylidene]-eth-(E)-ylidene]-1-((R)-1,5-dimethyl-5-trimethylsilanyloxy-hexyl)-8a-methyl-decahydro-azulene

Chemical Property:

Purity/Quality:: 98% ^*data from raw suppliers

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Technology Process of (1R,3aS,8aS)-5-[2-[(3S,5R)-3,5-Bis-(tert-butyl-dimethyl-silanyloxy)-2-methylene-cyclohex-(Z)-ylidene]-eth-(E)-ylidene]-1-((R)-1,5-dimethyl-5-trimethylsilanyloxy-hexyl)-8a-methyl-decahydro-azulene

There total 2 articles about (1R,3aS,8aS)-5-[2-[(3S,5R)-3,5-Bis-(tert-butyl-dimethyl-silanyloxy)-2-methylene-cyclohex-(Z)-ylidene]-eth-(E)-ylidene]-1-((R)-1,5-dimethyl-5-trimethylsilanyloxy-hexyl)-8a-methyl-decahydro-azulene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 145459-11-6
<1R,<1α(R^*),3aβ,8aα>>-octahydro-1-(1,5-dimethyl-5-hydroxyhexyl)-8a-methyl-5(1H)-azulenone

: 145459-14-9
(1R,3aS,8aS)-5-[2-[(3S,5R)-3,5-Bis-(tert-butyl-dimethyl-silanyloxy)-2-methylene-cyclohex-(Z)-ylidene]-eth-(E)-ylidene]-1-((R)-1,5-dimethyl-5-trimethylsilanyloxy-hexyl)-8a-methyl-decahydro-azulene

Guidance literature:: Multi-step reaction with 2 steps

1: 76 percent / imidazole / diethyl ether / 3 h

2: 1.) n-butyllithium / 1.) THF, hexane, -78 deg C, 2.) THF, hexane, -78 deg C, 2 h

With 1H-imidazole; n-butyllithium; In diethyl ether;
DOI:10.1016/0039-128X(92)90099-U

Reference yield:

: 81522-68-1
[(2Z)-2-[(3S,5R)-3,5-bis(tert-butyldimethylsilanyloxy)-2-methylenecyclohexylidene]ethyl]diphenylphosphine oxide

: 145459-13-8
<1R,<1α(R^*),3aβ,8aα>>-octahydro-8a-methyl-1-<1,5-dimethyl-5-<(trimethylsilyl)oxy>hexyl>-5(1H)-azulenone

: 145459-14-9
(1R,3aS,8aS)-5-[2-[(3S,5R)-3,5-Bis-(tert-butyl-dimethyl-silanyloxy)-2-methylene-cyclohex-(Z)-ylidene]-eth-(E)-ylidene]-1-((R)-1,5-dimethyl-5-trimethylsilanyloxy-hexyl)-8a-methyl-decahydro-azulene

Guidance literature:: With n-butyllithium; Yield given. Multistep reaction; 1.) THF, hexane, -78 deg C, 2.) THF, hexane, -78 deg C, 2 h;
DOI:10.1016/0039-128X(92)90099-U