tert-butyl (3S,αR)-3-(N-benzyl-N-α-methylbenzylamino)-3-(3,4-dimethoxyphenyl)propanoate

Base Information

Chemical Name:tert-butyl (3S,αR)-3-(N-benzyl-N-α-methylbenzylamino)-3-(3,4-dimethoxyphenyl)propanoate
CAS No.:496912-12-0
Molecular Formula:C₃₀H₃₇NO₄
Molecular Weight:475.628
Hs Code.:

Synonyms:tert-butyl (3S,αR)-3-(N-benzyl-N-α-methylbenzylamino)-3-(3,4-dimethoxyphenyl)propanoate

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Chemical Property of tert-butyl (3S,αR)-3-(N-benzyl-N-α-methylbenzylamino)-3-(3,4-dimethoxyphenyl)propanoate

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Technology Process of tert-butyl (3S,αR)-3-(N-benzyl-N-α-methylbenzylamino)-3-(3,4-dimethoxyphenyl)propanoate

There total 5 articles about tert-butyl (3S,αR)-3-(N-benzyl-N-α-methylbenzylamino)-3-(3,4-dimethoxyphenyl)propanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

: 40918-98-7
(E)-3-(3,4-dimethoxyphenyl)acrylic acid tert-butyl ester

: 38235-77-7
(R)-N-benzyl-1-phenylethylamine

: 496912-12-0
tert-butyl (3S,αR)-3-(N-benzyl-N-α-methylbenzylamino)-3-(3,4-dimethoxyphenyl)propanoate

Guidance literature:: (R)-N-benzyl-1-phenylethylamine; With n-butyllithium; In tetrahydrofuran; hexane; at -78 ℃; for 1h;

(E)-3-(3,4-dimethoxyphenyl)acrylic acid tert-butyl ester; In tetrahydrofuran; hexane; at -70 ℃; for 2h;
DOI:10.1055/s-2002-34389

Reference yield:

: 14737-89-4
3,4-dimethoxy-trans-cinnamic acid

: 496912-12-0
tert-butyl (3S,αR)-3-(N-benzyl-N-α-methylbenzylamino)-3-(3,4-dimethoxyphenyl)propanoate

Guidance literature:: Multi-step reaction with 3 steps

1.1: (COCl)2 / CH₂Cl₂ / 3 h / 20 °C

2.1: 39.44 g / CH₂Cl₂ / 20 °C

3.1: BuLi / tetrahydrofuran; hexane / 1 h / -78 °C

3.2: 97 percent / tetrahydrofuran; hexane / 2 h / -70 °C

With n-butyllithium; oxalyl dichloride; In tetrahydrofuran; hexane; dichloromethane;
DOI:10.1055/s-2002-34389

Reference yield:

: 39856-08-1,141236-46-6
(E)-3,4-dimethoxycinnamic chloride

: 496912-12-0
tert-butyl (3S,αR)-3-(N-benzyl-N-α-methylbenzylamino)-3-(3,4-dimethoxyphenyl)propanoate

Guidance literature:: Multi-step reaction with 2 steps

1.1: 39.44 g / CH₂Cl₂ / 20 °C

2.1: BuLi / tetrahydrofuran; hexane / 1 h / -78 °C

2.2: 97 percent / tetrahydrofuran; hexane / 2 h / -70 °C

With n-butyllithium; In tetrahydrofuran; hexane; dichloromethane;
DOI:10.1055/s-2002-34389