1-{4-chloro-3-[1-(4-ethyloxyphenyl)(methoxy)methyl]phenyl}-1-deoxy-β-D-glucopyranose

Base Information

Chemical Name:1-{4-chloro-3-[1-(4-ethyloxyphenyl)(methoxy)methyl]phenyl}-1-deoxy-β-D-glucopyranose
CAS No.:1318794-28-3
Molecular Formula:C₂₂H₂₇ClO₇
Molecular Weight:438.905
Hs Code.:

Synonyms:1-{4-chloro-3-[1-(4-ethyloxyphenyl)(methoxy)methyl]phenyl}-1-deoxy-β-D-glucopyranose

Suppliers and Price of 1-{4-chloro-3-[1-(4-ethyloxyphenyl)(methoxy)methyl]phenyl}-1-deoxy-β-D-glucopyranose

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Total 4 raw suppliers

Chemical Property of 1-{4-chloro-3-[1-(4-ethyloxyphenyl)(methoxy)methyl]phenyl}-1-deoxy-β-D-glucopyranose

Chemical Property:

Purity/Quality:: NLT 98% ^*data from raw suppliers

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Technology Process of 1-{4-chloro-3-[1-(4-ethyloxyphenyl)(methoxy)methyl]phenyl}-1-deoxy-β-D-glucopyranose

There total 11 articles about 1-{4-chloro-3-[1-(4-ethyloxyphenyl)(methoxy)methyl]phenyl}-1-deoxy-β-D-glucopyranose which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 461432-22-4
(5-bromo-2-chlorophenyl)(4-ethyloxyphenyl)methanone

: 1318794-28-3
1-{4-chloro-3-[1-(4-ethyloxyphenyl)(methoxy)methyl]phenyl}-1-deoxy-β-D-glucopyranose

Guidance literature:: Multi-step reaction with 7 steps

1.1: lithium aluminium tetrahydride / tetrahydrofuran / 1 h / Cooling with ice

1.2: pH 2 - 3 / Cooling with ice

2.1: sodium hydride / tetrahydrofuran / 1 h / Cooling with ice

2.2: 20 °C

3.1: n-butyllithium / tetrahydrofuran / 1 h / -78 °C / Sealed flask

3.2: 1 h

4.1: methanesulfonic acid / toluene; tetrahydrofuran / 20 °C

5.1: boron trifluoride diethyl etherate; triethylsilane / dichloromethane / 20 °C / Cooling with ice

6.1: sodium acetate / 1 h / Reflux

7.1: sodium methylate / methanol / 5 h / 20 °C

7.2: acidic resin / 20 °C

With triethylsilane; lithium aluminium tetrahydride; n-butyllithium; methanesulfonic acid; boron trifluoride diethyl etherate; sodium methylate; sodium acetate; sodium hydride; In tetrahydrofuran; methanol; dichloromethane; toluene;

Reference yield:

: 1318794-60-3
2,3,4,6-tetra-O-acetyl-1-{4-chloro-3-[(4-ethyloxyphenyl)(methoxyl)methyl]phenyl}-1-deoxy-β-D-glucopyranose

: 1318794-28-3
1-{4-chloro-3-[1-(4-ethyloxyphenyl)(methoxy)methyl]phenyl}-1-deoxy-β-D-glucopyranose

Guidance literature:: 2,3,4,6-tetra-O-acetyl-1-{4-chloro-3-[(4-ethyloxyphenyl)(methoxyl)methyl]phenyl}-1-deoxy-β-D-glucopyranose; With sodium methylate; In methanol; at 20 ℃; for 5h;

In methanol; at 20 ℃;

Reference yield:

: 21739-92-4
5-bromo-2-chlorobenzoic acid

: 1318794-28-3
1-{4-chloro-3-[1-(4-ethyloxyphenyl)(methoxy)methyl]phenyl}-1-deoxy-β-D-glucopyranose

Guidance literature:: Multi-step reaction with 9 steps

1.1: oxalyl dichloride / N,N-dimethyl-formamide / dichloromethane / 20 °C

2.1: aluminum (III) chloride / dichloromethane / 2 h / 0 - 20 °C

2.2: Cooling with ice

3.1: lithium aluminium tetrahydride / tetrahydrofuran / 1 h / Cooling with ice

3.2: pH 2 - 3 / Cooling with ice

4.1: sodium hydride / tetrahydrofuran / 1 h / Cooling with ice

4.2: 20 °C

5.1: n-butyllithium / tetrahydrofuran / 1 h / -78 °C / Sealed flask

5.2: 1 h

6.1: methanesulfonic acid / toluene; tetrahydrofuran / 20 °C

7.1: boron trifluoride diethyl etherate; triethylsilane / dichloromethane / 20 °C / Cooling with ice

8.1: sodium acetate / 1 h / Reflux

9.1: sodium methylate / methanol / 5 h / 20 °C

9.2: acidic resin / 20 °C

With triethylsilane; aluminum (III) chloride; lithium aluminium tetrahydride; n-butyllithium; oxalyl dichloride; methanesulfonic acid; boron trifluoride diethyl etherate; sodium methylate; sodium acetate; sodium hydride; N,N-dimethyl-formamide; In tetrahydrofuran; methanol; dichloromethane; toluene;