3-(4-chlorophenyl)-5-fluoro-3-hydroxy-2-(4-nitrobenzyl)isoindolin-1-one

Base Information

• Chemical Name: 3-(4-chlorophenyl)-5-fluoro-3-hydroxy-2-(4-nitrobenzyl)isoindolin-1-one
• CAS No.: 1202803-90-4
• Molecular Formula: C₂₁H₁₄ClFN₂O₄
• Molecular Weight: 412.805
• Mol file: 1202803-90-4.mol

Synonyms:3-(4-chlorophenyl)-5-fluoro-3-hydroxy-2-(4-nitrobenzyl)isoindolin-1-one

Chemical Property of 3-(4-chlorophenyl)-5-fluoro-3-hydroxy-2-(4-nitrobenzyl)isoindolin-1-one

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 3-(4-chlorophenyl)-5-fluoro-3-hydroxy-2-(4-nitrobenzyl)isoindolin-1-one

There total 1 articles about 3-(4-chlorophenyl)-5-fluoro-3-hydroxy-2-(4-nitrobenzyl)isoindolin-1-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

C14H7Cl2FO2 + 4-nitrobenzylamine hydrochloride (18600-42-5) → 3-(4-chlorophenyl)-6-fluoro-3-hydroxy-2-(4-nitrobenzyl)isoindolin-1-one (1202803-91-5) + 3-(4-chlorophenyl)-5-fluoro-3-hydroxy-2-(4-nitrobenzyl)isoindolin-1-one (1202803-90-4)

Guidance literature:

With N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; at 20 ℃; for 16h;

DOI:10.1016/j.bmcl.2011.07.084

Reference yield:

3-(4-chlorophenyl)-5-fluoro-3-hydroxy-2-(4-nitrobenzyl)isoindolin-1-one (1202803-90-4) → C21H13Cl2FN2O3

Guidance literature:

With thionyl chloride; N,N-dimethyl-formamide; In tetrahydrofuran; at 20 ℃; for 4h; Inert atmosphere;

DOI:10.1016/j.bmcl.2011.07.084

Reference yield:

3-(4-chlorophenyl)-5-fluoro-3-hydroxy-2-(4-nitrobenzyl)isoindolin-1-one (1202803-90-4) → 3-(4-chlorophenyl)-5-fluoro-3-((1-(hydroxymethyl)cyclopropyl)methoxy)-2-(4-nitrobenzyl)isoindolin-1-one (1202803-99-3)

Guidance literature:

Multi-step reaction with 2 steps

1: thionyl chloride; N,N-dimethyl-formamide / tetrahydrofuran / 4 h / 20 °C / Inert atmosphere

2: potassium carbonate / tetrahydrofuran / 16 h / 20 °C / Inert atmosphere

With thionyl chloride; potassium carbonate; N,N-dimethyl-formamide; In tetrahydrofuran;

DOI:10.1016/j.bmcl.2011.07.084

upstream raw materials:

4-nitrobenzylamine hydrochloride

Downstream raw materials:

3-(4-chlorophenyl)-5-fluoro-3-((1-(hydroxymethyl)cyclopropyl)methoxy)-2-(4-nitrobenzyl)isoindolin-1-one