(S)-2-{4-[2-(2,4-diamino-quinazolin-6-yl)-ethyl]-benzoylamino}-4-methylene-pentanedioic acid dimethyl ester

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Chemical Name:(S)-2-{4-[2-(2,4-diamino-quinazolin-6-yl)-ethyl]-benzoylamino}-4-methylene-pentanedioic acid dimethyl ester
CAS No.:1190062-80-6
Molecular Formula:C₂₅H₂₇N₅O₅
Molecular Weight:477.52
Hs Code.:

Synonyms:(S)-2-{4-[2-(2,4-diamino-quinazolin-6-yl)-ethyl]-benzoylamino}-4-methylene-pentanedioic acid dimethyl ester

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Chemical Property of (S)-2-{4-[2-(2,4-diamino-quinazolin-6-yl)-ethyl]-benzoylamino}-4-methylene-pentanedioic acid dimethyl ester

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Technology Process of (S)-2-{4-[2-(2,4-diamino-quinazolin-6-yl)-ethyl]-benzoylamino}-4-methylene-pentanedioic acid dimethyl ester

There total 1 articles about (S)-2-{4-[2-(2,4-diamino-quinazolin-6-yl)-ethyl]-benzoylamino}-4-methylene-pentanedioic acid dimethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.0%

: 1190062-79-3
(S)-2-amino-4-methylene-pentanedioic acid dimethyl ester hydrochloride

: 227016-65-1
4-amino-4-deoxy-5,8,10-trideazapteroic acid

: 1190062-80-6
(S)-2-{4-[2-(2,4-diamino-quinazolin-6-yl)-ethyl]-benzoylamino}-4-methylene-pentanedioic acid dimethyl ester

Guidance literature:: With 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; dmap; benzotriazol-1-ol; In N,N-dimethyl-formamide; at 55 ℃; for 4h;

Reference yield: 95.0%

: 1190062-80-6
(S)-2-{4-[2-(2,4-diamino-quinazolin-6-yl)-ethyl]-benzoylamino}-4-methylene-pentanedioic acid dimethyl ester

: (L)-4'-methylene-5,8,10-trideazaaminopterin

Guidance literature:: (S)-2-{4-[2-(2,4-diamino-quinazolin-6-yl)-ethyl]-benzoylamino}-4-methylene-pentanedioic acid dimethyl ester; With water; sodium hydroxide; In acetonitrile; at 10 - 20 ℃;

With hydrogenchloride; In water; acetonitrile; pH=5.5; Product distribution / selectivity;