6-Chloro-4-hydroxyquinoline-3-carboxylic acid

Base Information

Chemical Name:6-Chloro-4-hydroxyquinoline-3-carboxylic acid
CAS No.:35973-14-9
Molecular Formula:C10H6ClNO3
Molecular Weight:223.61
Hs Code.:2933499090
NSC Number:79880
DSSTox Substance ID:DTXSID10957399
Nikkaji Number:J1.713.562G,J783.259A
Wikidata:Q72452022
ChEMBL ID:CHEMBL216408
Mol file:35973-14-9.mol

Synonyms:6-Chloro-4-hydroxyquinoline-3-carboxylic acid;35973-14-9;53977-19-8;6-Chloro-4-oxo-1,4-dihydro-quinoline-3-carboxylic acid;6-chloro-4-oxo-1,4-dihydroquinoline-3-carboxylic acid;6-chloro-4-oxo-1H-quinoline-3-carboxylic acid;6-CHLORO-4-HYDROXY-3-QUINOLINECARBOXYLIC ACID;MFCD00065198;MFCD01829307;NSC79880;6-Chloro-4-hydroxy-quinoline-3-carboxylic acid;NCIOpen2_004176;Oprea1_414547;Oprea1_490985;SCHEMBL398364;CHEMBL216408;DTXSID10957399;CDPXSMNKRFLXHU-UHFFFAOYSA-N;AB2766;BBL028102;NSC-79880;STK653798;STK787537;AKOS000273156;AKOS002336633;AB02612;SB68639;VS-08667;BB 0222258;BB 0256689;CS-0206634;CS-0356761;FT-0621050;FT-0677189;EN300-77745;3-Quinolinecarboxylic acid, 6-chloro-4-hydroxy-;6-Chloro-4-hydroxy-quinoline-3-carboxylic acid;A823068;SR-01000425955;J-650142;SR-01000425955-1;BRD-K03391409-001-01-0;Z431512406;6-Chloro-1,4-dihydro-4-oxo-1H-quinoline-3-carboxylic acid

Suppliers and Price of 6-Chloro-4-hydroxyquinoline-3-carboxylic acid

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
6-Chloro-4-hydroxyquinoline-3-carboxylicAcid
250mg
$ 75.00

SynQuest Laboratories
6-Chloro-4-hydroxyquinoline-3-carboxylic acid
1 g
$ 176.00

SynQuest Laboratories
6-Chloro-4-hydroxyquinoline-3-carboxylic acid
5 g
$ 360.00

Crysdot
6-Chloro-4-hydroxyquinoline-3-carboxylicacid 95+%
5g
$ 333.00

Crysdot
6-Chloro-4-hydroxyquinoline-3-carboxylicacid 95+%
10g
$ 532.00

Crysdot
6-Chloro-4-hydroxyquinoline-3-carboxylicacid 95+%
25g
$ 1045.00

Chemenu
6-chloro-4-hydroxyquinoline-3-carboxylicacid 95%
25g
$ 978.00

Chemenu
6-chloro-4-hydroxyquinoline-3-carboxylicacid 95%
5g
$ 311.00

Chemenu
6-chloro-4-hydroxyquinoline-3-carboxylicacid 95%
10g
$ 497.00

Chemcia Scientific
6-Chloro-4-hydroxy-quinoline-3-carboxylicacid >95%
25 G
$ 1100.00

Total 31 raw suppliers

Chemical Property of 6-Chloro-4-hydroxyquinoline-3-carboxylic acid

Chemical Property:

Vapor Pressure:4.36E-07mmHg at 25°C
Refractive Index:1.648
Boiling Point:416.49 °C at 760 mmHg
Flash Point:205.686 °C
PSA：70.42000
Density:1.601 g/cm³
LogP:2.29200
Storage Temp.:2-8°C
XLogP3:2.5
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:4
Rotatable Bond Count:1
Exact Mass:223.0036207
Heavy Atom Count:15
Complexity:340

Purity/Quality:

97% ^*data from raw suppliers

6-Chloro-4-hydroxyquinoline-3-carboxylicAcid ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:C1=CC2=C(C=C1Cl)C(=O)C(=CN2)C(=O)O

Technology Process of 6-Chloro-4-hydroxyquinoline-3-carboxylic acid

There total 5 articles about 6-Chloro-4-hydroxyquinoline-3-carboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

: 70271-77-1
6-chloro-4-hydroxyquinoline-3-carboxylic acid ethyl ester

: 35973-14-9
6-chloro-4-hydroxy-3-quinoline carboxylic acid

Guidance literature:: With potassium hydroxide;
DOI:10.1007/BF01169674

Reference yield:

: 19056-79-2
diethyl 4-chloroanilinomethylenemalonate

: 35973-14-9
6-chloro-4-hydroxy-3-quinoline carboxylic acid

Guidance literature:: Multi-step reaction with 2 steps

1: 60 percent / diphenyl ether / 0.75 h / Heating

2: 2 N aq. NaOH / 1.5 h / Heating

With sodium hydroxide; In diphenylether;
DOI:10.1002/jhet.5570340149

Reference yield:

: 106-47-8
4-chloro-aniline

: 35973-14-9
6-chloro-4-hydroxy-3-quinoline carboxylic acid

Guidance literature:: Multi-step reaction with 3 steps

2: paraffin / 260 °C

3: aqueous NaOH

With sodium hydroxide; paraffin;
DOI:10.1021/ja01211a044