(3S,4S,αS)-N(1)-benzyl-3-methoxy-4-[N'-methyl-N'-(α-methylbenzyl)amino]pyrrolidine

Base Information

Chemical Name:(3S,4S,αS)-N(1)-benzyl-3-methoxy-4-[N'-methyl-N'-(α-methylbenzyl)amino]pyrrolidine
CAS No.:945483-46-5
Molecular Formula:C₂₁H₂₈N₂O
Molecular Weight:324.466
Hs Code.:

Synonyms:(3S,4S,αS)-N(1)-benzyl-3-methoxy-4-[N'-methyl-N'-(α-methylbenzyl)amino]pyrrolidine

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Chemical Property of (3S,4S,αS)-N(1)-benzyl-3-methoxy-4-[N'-methyl-N'-(α-methylbenzyl)amino]pyrrolidine

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Technology Process of (3S,4S,αS)-N(1)-benzyl-3-methoxy-4-[N'-methyl-N'-(α-methylbenzyl)amino]pyrrolidine

There total 6 articles about (3S,4S,αS)-N(1)-benzyl-3-methoxy-4-[N'-methyl-N'-(α-methylbenzyl)amino]pyrrolidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

: 945483-45-4
(3R,4S,αS)-N(1)-benzyl-3-methoxy-4-[N'-methyl-N'-(α-methylbenzyl)amino]pyrrolid-2-one

: 945483-46-5
(3S,4S,αS)-N(1)-benzyl-3-methoxy-4-[N'-methyl-N'-(α-methylbenzyl)amino]pyrrolidine

Guidance literature:: With lithium aluminium tetrahydride; In tetrahydrofuran; for 12h; Heating;
DOI:10.1039/b704932c

Reference yield:

: 945483-25-0
methyl (E)-(N-allyl-N-benzylamino)but-2-enoate

: 945483-46-5
(3S,4S,αS)-N(1)-benzyl-3-methoxy-4-[N'-methyl-N'-(α-methylbenzyl)amino]pyrrolidine

Guidance literature:: Multi-step reaction with 6 steps

1.1: 91 percent / BuLi / hexane; tetrahydrofuran / 2 h / -78 °C

2.1: 1,3-dimethyl barbituric acid / Pd(PPh₃)4 / CH₂Cl₂ / 12 h / 20 °C

3.1: 455 mg / SiO₂ / CH₂Cl₂

4.1: BuLi; 2,2,6,6-tetramethylpiperidine / hexane; tetrahydrofuran / 2 h / -78 °C

4.2: 86 percent / (+)-(camphorsulfonyl)oxaziridine / tetrahydrofuran; hexane / 16 h / -78 - 20 °C

5.1: 95 percent / NaH / tetrahydrofuran / 12 h / 0 - 20 °C

6.1: 94 percent / LiAlH₄ / tetrahydrofuran / 12 h / Heating

With 2,2,6,6-tetramethyl-piperidine; lithium aluminium tetrahydride; n-butyllithium; silica gel; sodium hydride; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; hexane; dichloromethane;
DOI:10.1039/b704932c

Reference yield:

: 906750-09-2
methyl (3R,αS)-3-[N-methyl-N-(α-methylbenzyl)amino]-4-(N'-benzyl-N'-allylamino)butanoate

: 945483-46-5
(3S,4S,αS)-N(1)-benzyl-3-methoxy-4-[N'-methyl-N'-(α-methylbenzyl)amino]pyrrolidine

Guidance literature:: Multi-step reaction with 5 steps

1.1: 1,3-dimethyl barbituric acid / Pd(PPh₃)4 / CH₂Cl₂ / 12 h / 20 °C

2.1: 455 mg / SiO₂ / CH₂Cl₂

3.1: BuLi; 2,2,6,6-tetramethylpiperidine / hexane; tetrahydrofuran / 2 h / -78 °C

3.2: 86 percent / (+)-(camphorsulfonyl)oxaziridine / tetrahydrofuran; hexane / 16 h / -78 - 20 °C

4.1: 95 percent / NaH / tetrahydrofuran / 12 h / 0 - 20 °C

5.1: 94 percent / LiAlH₄ / tetrahydrofuran / 12 h / Heating

With 2,2,6,6-tetramethyl-piperidine; lithium aluminium tetrahydride; n-butyllithium; silica gel; sodium hydride; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; hexane; dichloromethane;
DOI:10.1039/b704932c