Technology Process of 2-((2-(3-chloro-4-(cyclopropylmethoxy)phenyl)-4,5,6,7-tetrahydro-1,3-benzoxazol-5-yl)oxy)-1-(morpholin-4-yl)ethanone
There total 8 articles about 2-((2-(3-chloro-4-(cyclopropylmethoxy)phenyl)-4,5,6,7-tetrahydro-1,3-benzoxazol-5-yl)oxy)-1-(morpholin-4-yl)ethanone which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
With
potassium tert-butylate;
In
tetrahydrofuran;
for 1h;
Inert atmosphere;
- Guidance literature:
-
Multi-step reaction with 5 steps
1.1: hydrogen; palladium 10% on activated carbon / water; ethanol / 2 h / 20 °C / 3800.26 Torr
2.1: oxalyl dichloride; N,N-dimethyl-formamide / water; ethanol / 0.5 h / 20 °C
2.2: 0.5 h / 20 °C
3.1: sulfur trioxide pyridine complex; triethylamine / dimethyl sulfoxide / 1 h / Inert atmosphere
3.2: 1 h / 60 °C
4.1: hydrogenchloride / methanol; tetrahydrofuran; water / 1 h / 70 °C
4.2: 0.33 h / 20 °C
5.1: potassium tert-butylate / tetrahydrofuran / 1 h / Inert atmosphere
With
hydrogenchloride; oxalyl dichloride; palladium 10% on activated carbon; potassium tert-butylate; hydrogen; sulfur trioxide pyridine complex; triethylamine; N,N-dimethyl-formamide;
In
tetrahydrofuran; methanol; ethanol; water; dimethyl sulfoxide;
- Guidance literature:
-
Multi-step reaction with 6 steps
1.1: isopropyl alcohol / 90 °C
2.1: hydrogen; palladium 10% on activated carbon / water; ethanol / 2 h / 20 °C / 3800.26 Torr
3.1: oxalyl dichloride; N,N-dimethyl-formamide / water; ethanol / 0.5 h / 20 °C
3.2: 0.5 h / 20 °C
4.1: sulfur trioxide pyridine complex; triethylamine / dimethyl sulfoxide / 1 h / Inert atmosphere
4.2: 1 h / 60 °C
5.1: hydrogenchloride / methanol; tetrahydrofuran; water / 1 h / 70 °C
5.2: 0.33 h / 20 °C
6.1: potassium tert-butylate / tetrahydrofuran / 1 h / Inert atmosphere
With
hydrogenchloride; oxalyl dichloride; palladium 10% on activated carbon; potassium tert-butylate; hydrogen; sulfur trioxide pyridine complex; triethylamine; N,N-dimethyl-formamide;
In
tetrahydrofuran; methanol; ethanol; water; dimethyl sulfoxide; isopropyl alcohol;
