(1R,2S)-2-(6-(4-cyano-2-fluorobenzyloxy)naphthalene-2-sulfonamido)cyclohexanecarboxylic acid

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Chemical Name:(1R,2S)-2-(6-(4-cyano-2-fluorobenzyloxy)naphthalene-2-sulfonamido)cyclohexanecarboxylic acid
CAS No.:1312919-88-2
Molecular Formula:C₂₅H₂₃FN₂O₅S
Molecular Weight:482.532
Hs Code.:

Synonyms:(1R,2S)-2-(6-(4-cyano-2-fluorobenzyloxy)naphthalene-2-sulfonamido)cyclohexanecarboxylic acid

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Chemical Property of (1R,2S)-2-(6-(4-cyano-2-fluorobenzyloxy)naphthalene-2-sulfonamido)cyclohexanecarboxylic acid

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Technology Process of (1R,2S)-2-(6-(4-cyano-2-fluorobenzyloxy)naphthalene-2-sulfonamido)cyclohexanecarboxylic acid

There total 4 articles about (1R,2S)-2-(6-(4-cyano-2-fluorobenzyloxy)naphthalene-2-sulfonamido)cyclohexanecarboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 67.0%

: 1312919-70-2
(1R,2S)-ethyl 2-(6-(4-cyano-2-fluorobenzyloxy)naphthalene-2-sulfonamido)cyclohexanecarboxylate

: 1312919-88-2
(1R,2S)-2-(6-(4-cyano-2-fluorobenzyloxy)naphthalene-2-sulfonamido)cyclohexanecarboxylic acid

Guidance literature:: (1R,2S)-ethyl 2-(6-(4-cyano-2-fluorobenzyloxy)naphthalene-2-sulfonamido)cyclohexanecarboxylate; With lithium hydroxide; In 1,4-dioxane; at 20 ℃; Inert atmosphere;

With hydrogenchloride; In water; pH=2; Inert atmosphere;
DOI:10.1016/j.ejmech.2011.04.011

Reference yield:

: 135-76-2
sodium 2-naphthol-6-sulfonate

: 1312919-88-2
(1R,2S)-2-(6-(4-cyano-2-fluorobenzyloxy)naphthalene-2-sulfonamido)cyclohexanecarboxylic acid

Guidance literature:: Multi-step reaction with 3 steps

1.1: sodium / ethanol / 20 °C / Inert atmosphere

1.2: 20 °C / Inert atmosphere

1.3: 0 - 20 °C / Inert atmosphere

2.1: triethylamine / dichloromethane / 24 h / 20 °C / Inert atmosphere

3.1: lithium hydroxide / 1,4-dioxane / 20 °C / Inert atmosphere

3.2: pH 2 / Inert atmosphere

With sodium; triethylamine; lithium hydroxide; In 1,4-dioxane; ethanol; dichloromethane;
DOI:10.1016/j.ejmech.2011.04.011

Reference yield:

: 105942-09-4
4-(bromomethyl)-3-fluorobenzonitrile

: 1312919-88-2
(1R,2S)-2-(6-(4-cyano-2-fluorobenzyloxy)naphthalene-2-sulfonamido)cyclohexanecarboxylic acid

Guidance literature:: Multi-step reaction with 3 steps

1.1: sodium / ethanol / 20 °C / Inert atmosphere

1.2: 20 °C / Inert atmosphere

1.3: 0 - 20 °C / Inert atmosphere

2.1: triethylamine / dichloromethane / 24 h / 20 °C / Inert atmosphere

3.1: lithium hydroxide / 1,4-dioxane / 20 °C / Inert atmosphere

3.2: pH 2 / Inert atmosphere

With sodium; triethylamine; lithium hydroxide; In 1,4-dioxane; ethanol; dichloromethane;
DOI:10.1016/j.ejmech.2011.04.011