(R)-2-(toluene-4-sulfonyloxymethyl)azetidinecarboxylic acid tert-butyl ester

Base Information

• Chemical Name: (R)-2-(toluene-4-sulfonyloxymethyl)azetidinecarboxylic acid tert-butyl ester
• CAS No.: 209328-49-4
• Molecular Formula: C₁₆H₂₃NO₅S
• Molecular Weight: 341.428
• Mol file: 209328-49-4.mol

Synonyms:(R)-2-(toluene-4-sulfonyloxymethyl)azetidinecarboxylic acid tert-butyl ester

Chemical Property of (R)-2-(toluene-4-sulfonyloxymethyl)azetidinecarboxylic acid tert-butyl ester

Chemical Property:

Purity/Quality:

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Technology Process of (R)-2-(toluene-4-sulfonyloxymethyl)azetidinecarboxylic acid tert-butyl ester

There total 1 articles about (R)-2-(toluene-4-sulfonyloxymethyl)azetidinecarboxylic acid tert-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.8%

p-toluenesulfonyl chloride (98-59-9) + (R)-1-t-butyloxycarbonyl-2-azetidinemethanol (161511-90-6) → (R)-2-(toluene-4-sulfonyloxymethyl)azetidinecarboxylic acid tert-butyl ester (209328-49-4)

Guidance literature:

With sodium hydroxide; triethylamine; In dichloromethane;

Reference yield: 56.0%

(R)-2-(toluene-4-sulfonyloxymethyl)azetidinecarboxylic acid tert-butyl ester (209328-49-4) + N-(5-tert-butylthiazol-2-yl)-5-chloro-2-methoxybenzamide (959749-16-7) → (S,Z)-tert-butyl 2-((5-tert-butyl-2-(5-chloro-2-methoxybenzoylimino)thiazol-3(2H)-yl)methyl)azetidine-1-carboxylate

Guidance literature:

N-(5-tert-butylthiazol-2-yl)-5-chloro-2-methoxybenzamide; With sodium hydride; In N,N-dimethyl-formamide; mineral oil; at 0 ℃; for 0.5h;

(R)-2-(toluene-4-sulfonyloxymethyl)azetidinecarboxylic acid tert-butyl ester; In N,N-dimethyl-formamide; mineral oil; at 20 ℃; for 18h;

upstream raw materials:

p-toluenesulfonyl chloride

(R)-1-t-butyloxycarbonyl-2-azetidinemethanol