(+)-(3R,4R,5R)-4-acetoxy-5-isopropyl-2-methyl-3-(N-methyl-N-trichloroacetylamino)-cyclohex-1-ene

Base Information

Chemical Name:(+)-(3R,4R,5R)-4-acetoxy-5-isopropyl-2-methyl-3-(N-methyl-N-trichloroacetylamino)-cyclohex-1-ene
CAS No.:345665-08-9
Molecular Formula:C₁₅H₂₂Cl₃NO₃
Molecular Weight:370.704
Hs Code.:

Synonyms:(+)-(3R,4R,5R)-4-acetoxy-5-isopropyl-2-methyl-3-(N-methyl-N-trichloroacetylamino)-cyclohex-1-ene

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Chemical Property of (+)-(3R,4R,5R)-4-acetoxy-5-isopropyl-2-methyl-3-(N-methyl-N-trichloroacetylamino)-cyclohex-1-ene

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Technology Process of (+)-(3R,4R,5R)-4-acetoxy-5-isopropyl-2-methyl-3-(N-methyl-N-trichloroacetylamino)-cyclohex-1-ene

There total 7 articles about (+)-(3R,4R,5R)-4-acetoxy-5-isopropyl-2-methyl-3-(N-methyl-N-trichloroacetylamino)-cyclohex-1-ene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 108-24-7
acetic anhydride

: 2,2,2-trichloro-N-(6-hydroxy-5-isopropyl-2-methyl-cyclohex-2-enyl)-N-methyl-acetamide

: 345665-08-9
(+)-(3R,4R,5R)-4-acetoxy-5-isopropyl-2-methyl-3-(N-methyl-N-trichloroacetylamino)-cyclohex-1-ene

Guidance literature:: With triethylamine; In diethyl ether; at 20 ℃; for 1h;
DOI:10.1016/S0022-328X(01)00662-3

Reference yield:

: 22339-08-8
(+)-trans-verbenol

: 345665-08-9
(+)-(3R,4R,5R)-4-acetoxy-5-isopropyl-2-methyl-3-(N-methyl-N-trichloroacetylamino)-cyclohex-1-ene

Guidance literature:: Multi-step reaction with 7 steps

1: tetrahydrofuran / 2 h / 20 °C

2: Et₃N / tetrahydrofuran / 12 h / 20 °C

3: 24.5 g / Et₃N / tetrahydrofuran / 2 h / 20 °C

4: 71 percent / Bu₃SnH; 1,1'-azobis(cyclohexanecarbonitrile) / toluene / 3 h / Heating

5: 570 mg / KOH; H₂O / ethanol / 2 h / Heating

6: Et₃N; MeOH / diethyl ether / 1 h / 20 °C

7: 482 mg / Et₃N / diethyl ether / 1 h / 20 °C

With methanol; potassium hydroxide; water; tri-n-butyl-tin hydride; triethylamine; 1,1'-azobis(1-cyanocyclohexanenitrile); In tetrahydrofuran; diethyl ether; ethanol; toluene;
DOI:10.1016/S0022-328X(01)00662-3

Reference yield:

: 242130-26-3
(+)-(3aS,7R,7aR)-7-isopropyl-3,4-dimethyl-3a,6,7,7a-tetrahydro-3H-benzoxazol-2-one

: 345665-08-9
(+)-(3R,4R,5R)-4-acetoxy-5-isopropyl-2-methyl-3-(N-methyl-N-trichloroacetylamino)-cyclohex-1-ene

Guidance literature:: Multi-step reaction with 3 steps

1: 570 mg / KOH; H₂O / ethanol / 2 h / Heating

2: Et₃N; MeOH / diethyl ether / 1 h / 20 °C

3: 482 mg / Et₃N / diethyl ether / 1 h / 20 °C

With methanol; potassium hydroxide; water; triethylamine; In diethyl ether; ethanol;
DOI:10.1016/S0022-328X(01)00662-3