dibenzyl (R)-[1-(3'-chlorobiphenyl-4-ylsulfonylamino)-2-methylpropyl]phosphonate

Base Information

Chemical Name:dibenzyl (R)-[1-(3'-chlorobiphenyl-4-ylsulfonylamino)-2-methylpropyl]phosphonate
CAS No.:925463-17-8
Molecular Formula:C₃₀H₃₁ClNO₅PS
Molecular Weight:584.073
Hs Code.:

Synonyms:dibenzyl (R)-[1-(3'-chlorobiphenyl-4-ylsulfonylamino)-2-methylpropyl]phosphonate

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Chemical Property of dibenzyl (R)-[1-(3'-chlorobiphenyl-4-ylsulfonylamino)-2-methylpropyl]phosphonate

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Technology Process of dibenzyl (R)-[1-(3'-chlorobiphenyl-4-ylsulfonylamino)-2-methylpropyl]phosphonate

There total 4 articles about dibenzyl (R)-[1-(3'-chlorobiphenyl-4-ylsulfonylamino)-2-methylpropyl]phosphonate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 55.0%

: 925463-07-6
dibenzyl (R)-N-(p-bromobenzenesulfonyl)-2-amino-2-methylpropylphosphonate

: 63503-60-6
3-chlorophenylboronic acid

: 925463-17-8
dibenzyl (R)-[1-(3'-chlorobiphenyl-4-ylsulfonylamino)-2-methylpropyl]phosphonate

Guidance literature:: With potassium phosphate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In toluene; for 24h; Heating;
DOI:10.1016/j.bmc.2006.10.047

Reference yield:

: 873586-57-3
(S)-p-bromobenzenesulfinamide

: 925463-17-8
dibenzyl (R)-[1-(3'-chlorobiphenyl-4-ylsulfonylamino)-2-methylpropyl]phosphonate

Guidance literature:: Multi-step reaction with 4 steps

1.1: titanium(IV) ethoxide / CH₂Cl₂ / 3 h / Heating

2.1: lithium bis(trimethylsilyl)amide / tetrahydrofuran / 0.5 h / -78 °C

2.2: 54 percent / tetrahydrofuran / 3 h / -78 °C

3.1: 97 percent / m-chloroperbenzoic acid / CH₂Cl₂ / 0.5 h / 0 °C

4.1: 55 percent / K₃PO₄ / Pd(PPh₃)4 / toluene / 24 h / Heating

With titanium(IV) tetraethanolate; potassium phosphate; 3-chloro-benzenecarboperoxoic acid; lithium hexamethyldisilazane; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; dichloromethane; toluene; 4.1: Suzuki coupling;
DOI:10.1016/j.bmc.2006.10.047

Reference yield:

: (S)-N-(2-methylpropylidene)-p-bromobenzenesulfinamide

: 925463-17-8
dibenzyl (R)-[1-(3'-chlorobiphenyl-4-ylsulfonylamino)-2-methylpropyl]phosphonate

Guidance literature:: Multi-step reaction with 3 steps

1.1: lithium bis(trimethylsilyl)amide / tetrahydrofuran / 0.5 h / -78 °C

1.2: 54 percent / tetrahydrofuran / 3 h / -78 °C

2.1: 97 percent / m-chloroperbenzoic acid / CH₂Cl₂ / 0.5 h / 0 °C

3.1: 55 percent / K₃PO₄ / Pd(PPh₃)4 / toluene / 24 h / Heating

With potassium phosphate; 3-chloro-benzenecarboperoxoic acid; lithium hexamethyldisilazane; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; dichloromethane; toluene; 3.1: Suzuki coupling;
DOI:10.1016/j.bmc.2006.10.047