3-(3-chlorophenyl)oxetane

Base Information

• Chemical Name: 3-(3-chlorophenyl)oxetane
• CAS No.: 1044507-51-8
• Molecular Formula: C₉H₉ClO
• Molecular Weight: 168.623
• Mol file: 1044507-51-8.mol

Synonyms:3-(3-chlorophenyl)oxetane

Chemical Property of 3-(3-chlorophenyl)oxetane

Chemical Property:

Purity/Quality:

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Technology Process of 3-(3-chlorophenyl)oxetane

There total 1 articles about 3-(3-chlorophenyl)oxetane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 65.0%

3-iodooxetane (26272-85-5) + 3-chlorophenylboronic acid (63503-60-6) → 3-(3-chlorophenyl)oxetane (1044507-51-8)

Guidance literature:

3-chlorophenylboronic acid; With nickel(II) iodide; trans-2-aminocyclohexanol hydrochloride; sodium hexamethyldisilazane; In isopropyl alcohol; Inert atmosphere;

3-iodooxetane; In isopropyl alcohol; at 80 ℃; for 0.333333h; Microwave irradiation;

DOI:10.1021/ol8011327

Reference yield: 90.0%

3-(3-chlorophenyl)oxetane (1044507-51-8) + 2-Mercaptobenzothiazole (149-30-4,118090-09-8) → (S)-3-(benzo[d]thiazol-2-ylthio)-2-(3-chlorophenyl)propan-1-ol

Guidance literature:

With (11aR)-3,7-di-9-anthracenyl-10,11,12,13-tetrahydro-5-hydroxy-5-oxide diindeno[7,1de:10,70-fg][1,3,2] dioxaphosphocin; In diethyl ether; at 20 ℃; for 48h; enantioselective reaction;

DOI:10.1002/anie.201300188

upstream raw materials:

3-iodooxetane

3-chlorophenylboronic acid