3-methoxy-7-phenyl-5,7-dihydro-6H-10-thia-7a,11-diaza-cyclopenta[b]phenanthren-8-one

Base Information

• Chemical Name: 3-methoxy-7-phenyl-5,7-dihydro-6H-10-thia-7a,11-diaza-cyclopenta[b]phenanthren-8-one
• CAS No.: 1379610-86-2
• Molecular Formula: C₂₁H₁₈N₂O₂S
• Molecular Weight: 362.452

Synonyms:3-methoxy-7-phenyl-5,7-dihydro-6H-10-thia-7a,11-diaza-cyclopenta[b]phenanthren-8-one

Chemical Property of 3-methoxy-7-phenyl-5,7-dihydro-6H-10-thia-7a,11-diaza-cyclopenta[b]phenanthren-8-one

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Technology Process of 3-methoxy-7-phenyl-5,7-dihydro-6H-10-thia-7a,11-diaza-cyclopenta[b]phenanthren-8-one

There total 5 articles about 3-methoxy-7-phenyl-5,7-dihydro-6H-10-thia-7a,11-diaza-cyclopenta[b]phenanthren-8-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 72.0%

8-methoxy-4-phenyl-3,4,5,6-tetrahydrobenzo[h]quinazoline-2(1H)-thione (353268-10-7) + chloroacetic acid (79-11-8) → 3-methoxy-7-phenyl-5,7-dihydro-6H-10-thia-7a,11-diaza-cyclopenta[b]phenanthren-8-one (1379610-86-2)

Guidance literature:

With N-methylpyridinium p-toluenesulfonate; at 100 - 110 ℃;

DOI:10.1080/10426507.2011.647145

Reference yield: 65.0%

8-methoxy-4-phenyl-3,4,5,6-tetrahydrobenzo[h]quinazoline-2(1H)-thione (353268-10-7) + N-chloroacetyl-aniline (587-65-5) → 3-methoxy-7-phenyl-5,7-dihydro-6H-10-thia-7a,11-diaza-cyclopenta[b]phenanthren-8-one (1379610-86-2)

Guidance literature:

With acetic acid; for 6h; Reagent/catalyst; Reflux;

DOI:10.1016/j.tetlet.2013.11.001

Reference yield: 63.0%

8-methoxy-4-phenyl-3,4,5,6-tetrahydrobenzo[h]quinazoline-2(1H)-thione (353268-10-7) + N-benzothiazol-2-yl-2-chloroacetamide (3028-02-2) → 3-methoxy-7-phenyl-5,7-dihydro-6H-10-thia-7a,11-diaza-cyclopenta[b]phenanthren-8-one (1379610-86-2)

Guidance literature:

With triethylamine; In 1,4-dioxane; for 5h; Reagent/catalyst; Reflux;

DOI:10.1016/j.tetlet.2013.11.001

upstream raw materials:

8-methoxy-4-phenyl-3,4,5,6-tetrahydrobenzo[h]quinazoline-2(1H)-thione

chloroacetic acid

benzaldehyde

6-methoxy-3,4-dihydro-1(2H)-naphthalenone

Downstream raw materials:

(E)-3-methoxy-10-(4-methylbenzylidene)-7-phenyl-7,10-dihydro-5H-benzo[h]thiazolo[2,3-b]quinazoline-9(6H)-one

(E)-3-methoxy-10-(4-methoxybenzylidene)-7-phenyl-7,10-dihydro-5H-benzo[h]-thiazoline-9(6H)-one

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