(3S)-3-[[(1R)-1-phenylethyl]-2-hydroxyethylamino]-4-methylpentanoic acid methyl ester

Base Information

Chemical Name:(3S)-3-[[(1R)-1-phenylethyl]-2-hydroxyethylamino]-4-methylpentanoic acid methyl ester
CAS No.:1589566-56-2
Molecular Formula:C₁₇H₂₇NO₃
Molecular Weight:293.406
Hs Code.:

Synonyms:(3S)-3-[[(1R)-1-phenylethyl]-2-hydroxyethylamino]-4-methylpentanoic acid methyl ester

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Chemical Property of (3S)-3-[[(1R)-1-phenylethyl]-2-hydroxyethylamino]-4-methylpentanoic acid methyl ester

Chemical Property:

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Technology Process of (3S)-3-[[(1R)-1-phenylethyl]-2-hydroxyethylamino]-4-methylpentanoic acid methyl ester

There total 5 articles about (3S)-3-[[(1R)-1-phenylethyl]-2-hydroxyethylamino]-4-methylpentanoic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

: 1589566-55-1
C₁₈H₂₉NO₄

: 1589566-56-2
(3S)-3-[[(1R)-1-phenylethyl]-2-hydroxyethylamino]-4-methylpentanoic acid methyl ester

Guidance literature:: C₁₈H₂₉NO₄; With sodium periodate; In tetrahydrofuran; water; at 20 ℃;

With sodium tetrahydroborate; In tetrahydrofuran; water; at 0 ℃; for 0.5h;
DOI:10.1007/s11426-014-5065-3

Reference yield:

: 3886-69-9
(R)-1-phenyl-ethyl-amine

: 1589566-56-2
(3S)-3-[[(1R)-1-phenylethyl]-2-hydroxyethylamino]-4-methylpentanoic acid methyl ester

Guidance literature:: Multi-step reaction with 4 steps

1.1: n-butyllithium / tetrahydrofuran / -50 - 20 °C

2.1: n-butyllithium / tetrahydrofuran; hexane / 0.75 h / -78 °C

2.2: 0.67 h / -78 °C

3.1: osmium(VIII) oxide; 4-methylmorpholine N-oxide / tetrahydrofuran; tert-butyl alcohol; water / 20 °C

4.1: sodium periodate / tetrahydrofuran; water / 20 °C

4.2: 0.5 h / 0 °C

With sodium periodate; osmium(VIII) oxide; n-butyllithium; 4-methylmorpholine N-oxide; In tetrahydrofuran; hexane; water; tert-butyl alcohol;
DOI:10.1007/s11426-014-5065-3

Reference yield:

: 1589566-48-2
(3S)-3-[[(1R)-1-phenylethyl]-2-propen-1-ylamino]-4-methylpentanoic acid methyl ester

: 1589566-56-2
(3S)-3-[[(1R)-1-phenylethyl]-2-hydroxyethylamino]-4-methylpentanoic acid methyl ester

Guidance literature:: Multi-step reaction with 2 steps

1.1: osmium(VIII) oxide; 4-methylmorpholine N-oxide / tetrahydrofuran; tert-butyl alcohol; water / 20 °C

2.1: sodium periodate / tetrahydrofuran; water / 20 °C

2.2: 0.5 h / 0 °C

With sodium periodate; osmium(VIII) oxide; 4-methylmorpholine N-oxide; In tetrahydrofuran; water; tert-butyl alcohol;
DOI:10.1007/s11426-014-5065-3