4-{3-[4-(2-methoxyphenyl)piperazin-1-yl]propoxy}-N-(propan-2-yl)aniline trihydrochloride

Base Information

• Chemical Name: 4-{3-[4-(2-methoxyphenyl)piperazin-1-yl]propoxy}-N-(propan-2-yl)aniline trihydrochloride
• CAS No.: 104655-21-2
• Molecular Formula: C₂₃H₃₃N₃O₂*3ClH
• Molecular Weight: 492.917
• Mol file: 104655-21-2.mol

Synonyms:Benzenamine,4-[3-[4-(2-methoxyphenyl)-1-piperazinyl]propoxy]-N-(1-methylethyl)-,trihydrochloride (9CI)

Chemical Property of 4-{3-[4-(2-methoxyphenyl)piperazin-1-yl]propoxy}-N-(propan-2-yl)aniline trihydrochloride

Chemical Property:

• Vapor Pressure: 2.21E-12mmHg at 25°C
• Boiling Point: 555.6°Cat760mmHg
• Flash Point: 289.8°C
• Density: g/cm³

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 4-{3-[4-(2-methoxyphenyl)piperazin-1-yl]propoxy}-N-(propan-2-yl)aniline trihydrochloride

There total 2 articles about 4-{3-[4-(2-methoxyphenyl)piperazin-1-yl]propoxy}-N-(propan-2-yl)aniline trihydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 62.0%

1-<4-(N-Isopropylidenamino)phenoxy>-3-1-4-(2-methoxyphenyl)piperazinyl>>propane (104655-12-1) → 1-<4-(N-Isopropylamino)phenoxy>-3-1-4-(2-methoxyphenyl)piperazinyl>>propane hydrochloride (104655-21-2)

Guidance literature:

With hydrogenchloride; sodium tetrahydroborate; In methanol; 1.) MeOH, 0 deg C, 4 h;

Reference yield:

1-(4-aminophenoxy)-3-1-4-(2-methoxyphenyl)-piperazinyl>>propane (104655-08-5) → 1-<4-(N-Isopropylamino)phenoxy>-3-1-4-(2-methoxyphenyl)piperazinyl>>propane hydrochloride (104655-21-2)

Guidance literature:

Multi-step reaction with 2 steps

1: 90 percent / 2 h / Heating

2: 62 percent / 1.) NaBH₄, 2.) HCl / methanol / 1.) MeOH, 0 deg C, 4 h

With hydrogenchloride; sodium tetrahydroborate; In methanol;

upstream raw materials:

1-<4-(N-Isopropylidenamino)phenoxy>-3-1-4-(2-methoxyphenyl)piperazinyl>>propane

1-(4-aminophenoxy)-3-1-4-(2-methoxyphenyl)-piperazinyl>>propane