(1R,6S)-6-benzoyl-1-[(4S)-4-isopropyl-1,3-thiazolidine-2-thion-3-yl]carbonylcyclohex-3-ene

Base Information

Chemical Name:(1R,6S)-6-benzoyl-1-[(4S)-4-isopropyl-1,3-thiazolidine-2-thion-3-yl]carbonylcyclohex-3-ene
CAS No.:857682-05-4
Molecular Formula:C₂₀H₂₃NO₂S₂
Molecular Weight:373.54
Hs Code.:

Synonyms:(1R,6S)-6-benzoyl-1-[(4S)-4-isopropyl-1,3-thiazolidine-2-thion-3-yl]carbonylcyclohex-3-ene

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Chemical Property of (1R,6S)-6-benzoyl-1-[(4S)-4-isopropyl-1,3-thiazolidine-2-thion-3-yl]carbonylcyclohex-3-ene

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Technology Process of (1R,6S)-6-benzoyl-1-[(4S)-4-isopropyl-1,3-thiazolidine-2-thion-3-yl]carbonylcyclohex-3-ene

There total 4 articles about (1R,6S)-6-benzoyl-1-[(4S)-4-isopropyl-1,3-thiazolidine-2-thion-3-yl]carbonylcyclohex-3-ene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 935-79-5
cis-1,2,3,6-tetrahydrophthalic anhydride

: 857682-05-4
(1R,6S)-6-benzoyl-1-[(4S)-4-isopropyl-1,3-thiazolidine-2-thion-3-yl]carbonylcyclohex-3-ene

Guidance literature:: Multi-step reaction with 4 steps

1: NaH / tetrahydrofuran; dimethylsulfoxide / 1 h / -50 - -40 °C

2: 56 percent / Et₃N / CH₂Cl₂ / 0.5 h / 20 °C

3: 72 percent / tetrahydrofuran / 12 h / 0 °C

4: 24 percent / DMAP; 1-ethyl-3-(3-dimethylaminopropyl)carbodiimide hydrochloride / CH₂Cl₂ / 1 h / 20 °C

With dmap; sodium hydride; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; In tetrahydrofuran; dichloromethane; dimethyl sulfoxide;
DOI:10.3987/COM-05-10356

Reference yield:

: racemic cis-6-(N-methoxy-N-methylaminocarbonyl)cyclohex-3-enecarboxylic acid

: 857682-05-4
(1R,6S)-6-benzoyl-1-[(4S)-4-isopropyl-1,3-thiazolidine-2-thion-3-yl]carbonylcyclohex-3-ene

Guidance literature:: Multi-step reaction with 2 steps

1: 72 percent / tetrahydrofuran / 12 h / 0 °C

2: 24 percent / DMAP; 1-ethyl-3-(3-dimethylaminopropyl)carbodiimide hydrochloride / CH₂Cl₂ / 1 h / 20 °C

With dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In tetrahydrofuran; dichloromethane;
DOI:10.3987/COM-05-10356

Reference yield:

: 6-((S)-4-Isopropyl-2-thioxo-thiazolidine-3-carbonyl)-cyclohex-3-enecarboxylic acid

: 857682-05-4
(1R,6S)-6-benzoyl-1-[(4S)-4-isopropyl-1,3-thiazolidine-2-thion-3-yl]carbonylcyclohex-3-ene

Guidance literature:: Multi-step reaction with 3 steps

1: 56 percent / Et₃N / CH₂Cl₂ / 0.5 h / 20 °C

2: 72 percent / tetrahydrofuran / 12 h / 0 °C

3: 24 percent / DMAP; 1-ethyl-3-(3-dimethylaminopropyl)carbodiimide hydrochloride / CH₂Cl₂ / 1 h / 20 °C

With dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; In tetrahydrofuran; dichloromethane;
DOI:10.3987/COM-05-10356