(R)-methyl 3-((naphthalen-2-ylmethyl)thio)-2-(6-phenylpicolinamido)propanoate

Base Information

Chemical Name:(R)-methyl 3-((naphthalen-2-ylmethyl)thio)-2-(6-phenylpicolinamido)propanoate
CAS No.:1361296-52-7
Molecular Formula:C₂₇H₂₄N₂O₃S
Molecular Weight:456.565
Hs Code.:

Synonyms:(R)-methyl 3-((naphthalen-2-ylmethyl)thio)-2-(6-phenylpicolinamido)propanoate

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Chemical Property of (R)-methyl 3-((naphthalen-2-ylmethyl)thio)-2-(6-phenylpicolinamido)propanoate

Chemical Property:

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Technology Process of (R)-methyl 3-((naphthalen-2-ylmethyl)thio)-2-(6-phenylpicolinamido)propanoate

There total 2 articles about (R)-methyl 3-((naphthalen-2-ylmethyl)thio)-2-(6-phenylpicolinamido)propanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 33.0%

: 39774-28-2
6-phenyl-pyridine-2-carboxylic acid

: 1361378-10-0
(R)-methyl 2-amino-3-((naphthalen-2-ylmethyl)thio)propanoate

: 1361296-52-7
(R)-methyl 3-((naphthalen-2-ylmethyl)thio)-2-(6-phenylpicolinamido)propanoate

Guidance literature:: With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; In dichloromethane; for 72h; Inert atmosphere;
DOI:10.1021/jm201417e

Reference yield:

: 939-26-4
2-bromomethylnaphthyl bromide

: 1361296-52-7
(R)-methyl 3-((naphthalen-2-ylmethyl)thio)-2-(6-phenylpicolinamido)propanoate

Guidance literature:: Multi-step reaction with 2 steps

1: triethylamine / dichloromethane / 48 h / 20 °C

2: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine / dichloromethane / 72 h / Inert atmosphere

With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; N-ethyl-N,N-diisopropylamine; In dichloromethane;
DOI:10.1021/jm201417e

Reference yield: 52.0%

: 1361296-52-7
(R)-methyl 3-((naphthalen-2-ylmethyl)thio)-2-(6-phenylpicolinamido)propanoate

: 1361296-40-3
(R)-3-((naphthalen-2-ylmethyl)thio)-2-(6-phenylpicolinamido)propanoic acid

Guidance literature:: (R)-methyl 3-((naphthalen-2-ylmethyl)thio)-2-(6-phenylpicolinamido)propanoate; With lithium hydroxide; In 1,4-dioxane; at 20 ℃; for 18h;

With acetic acid; In 1,4-dioxane; dichloromethane; pH=3;
DOI:10.1021/jm201417e