(S)-1-(Diphenyl-phosphinothioyl)-2-((S)-4-isopropyl-4,5-dihydro-oxazol-2-yl)-2,3-dihydro-1H-indole

Base Information

Chemical Name:(S)-1-(Diphenyl-phosphinothioyl)-2-((S)-4-isopropyl-4,5-dihydro-oxazol-2-yl)-2,3-dihydro-1H-indole
CAS No.:686275-04-7
Molecular Formula:C₂₆H₂₇N₂OPS
Molecular Weight:446.553
Hs Code.:

Synonyms:(S)-1-(Diphenyl-phosphinothioyl)-2-((S)-4-isopropyl-4,5-dihydro-oxazol-2-yl)-2,3-dihydro-1H-indole

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Chemical Property of (S)-1-(Diphenyl-phosphinothioyl)-2-((S)-4-isopropyl-4,5-dihydro-oxazol-2-yl)-2,3-dihydro-1H-indole

Chemical Property:

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Technology Process of (S)-1-(Diphenyl-phosphinothioyl)-2-((S)-4-isopropyl-4,5-dihydro-oxazol-2-yl)-2,3-dihydro-1H-indole

There total 5 articles about (S)-1-(Diphenyl-phosphinothioyl)-2-((S)-4-isopropyl-4,5-dihydro-oxazol-2-yl)-2,3-dihydro-1H-indole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 686275-03-6
(S)-1-(Diphenyl-phosphinothioyl)-2,3-dihydro-1H-indole-2-carboxylic acid ((S)-1-hydroxymethyl-2-methyl-propyl)-amide

: 686275-04-7
(S)-1-(Diphenyl-phosphinothioyl)-2-((S)-4-isopropyl-4,5-dihydro-oxazol-2-yl)-2,3-dihydro-1H-indole

Guidance literature:: With dmap; p-toluenesulfonyl chloride; In dichloromethane;
DOI:10.1016/j.tetasy.2004.01.002

Reference yield:

: 2026-48-4,473-75-6
(S)-valinol

: 686275-04-7
(S)-1-(Diphenyl-phosphinothioyl)-2-((S)-4-isopropyl-4,5-dihydro-oxazol-2-yl)-2,3-dihydro-1H-indole

Guidance literature:: Multi-step reaction with 2 steps

1: 100 percent / BOP; Et₃N / acetonitrile

2: p-TsCl; DMAP / CH₂Cl₂

With dmap; (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; triethylamine; p-toluenesulfonyl chloride; In dichloromethane; acetonitrile;
DOI:10.1016/j.tetasy.2004.01.002

Reference yield:

: 1-diphenylphosphanyl-2,3-dihydro-1H-indole-2-carboxylic acid methyl ester

: 686275-04-7
(S)-1-(Diphenyl-phosphinothioyl)-2-((S)-4-isopropyl-4,5-dihydro-oxazol-2-yl)-2,3-dihydro-1H-indole

Guidance literature:: Multi-step reaction with 4 steps

1: S₈ / toluene

2: LiOH / methanol

3: 100 percent / BOP; Et₃N / acetonitrile

4: p-TsCl; DMAP / CH₂Cl₂

With sulfur; dmap; lithium hydroxide; (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; triethylamine; p-toluenesulfonyl chloride; In methanol; dichloromethane; toluene; acetonitrile;
DOI:10.1016/j.tetasy.2004.01.002