methyl (S)-3-(4-hydroxyphenyl)-2-[(R)-2-{2-[4-methoxy-3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl]acetamido}-2-phenylacetamido]propanoate

Base Information

• Chemical Name: methyl (S)-3-(4-hydroxyphenyl)-2-[(R)-2-{2-[4-methoxy-3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl]acetamido}-2-phenylacetamido]propanoate
• CAS No.: 1200443-27-1
• Molecular Formula: C₃₃H₃₉BN₂O₈
• Molecular Weight: 602.492
• Mol file: 1200443-27-1.mol

Synonyms:methyl (S)-3-(4-hydroxyphenyl)-2-[(R)-2-{2-[4-methoxy-3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl]acetamido}-2-phenylacetamido]propanoate

Chemical Property of methyl (S)-3-(4-hydroxyphenyl)-2-[(R)-2-{2-[4-methoxy-3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl]acetamido}-2-phenylacetamido]propanoate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of methyl (S)-3-(4-hydroxyphenyl)-2-[(R)-2-{2-[4-methoxy-3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl]acetamido}-2-phenylacetamido]propanoate

There total 1 articles about methyl (S)-3-(4-hydroxyphenyl)-2-[(R)-2-{2-[4-methoxy-3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl]acetamido}-2-phenylacetamido]propanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 66.0%

2-(4-methoxy-3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)acetic acid (1200443-26-0) + C18H20N2O4*ClH (1200443-25-9) → methyl (S)-3-(4-hydroxyphenyl)-2-[(R)-2-{2-[4-methoxy-3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl]acetamido}-2-phenylacetamido]propanoate (1200443-27-1)

Guidance literature:

With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; In dichloromethane; at 25 ℃; for 2h; Inert atmosphere;

DOI:10.1055/s-0029-1216937

Reference yield: 90.0%

methyl (S)-3-(4-hydroxyphenyl)-2-[(R)-2-{2-[4-methoxy-3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl]acetamido}-2-phenylacetamido]propanoate (1200443-27-1) → 5-(2-{(R)-2-[(S)-3-(4-hydroxyphenyl)-1-methoxy-1-oxopropan-2-ylamino]-2-oxo-1-phenylethylamino}-2-oxoethyl)-2-methoxyphenylboronic acid (1200443-28-2)

Guidance literature:

With sodium periodate; ammonium acetate; In water; acetone; at 25 ℃; for 16h;

DOI:10.1055/s-0029-1216937

upstream raw materials:

2-(4-methoxy-3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)acetic acid

C₁₈H₂₀N₂O₄*ClH

Downstream raw materials:

5-(2-{(R)-2-[(S)-3-(4-hydroxyphenyl)-1-methoxy-1-oxopropan-2-ylamino]-2-oxo-1-phenylethylamino}-2-oxoethyl)-2-methoxyphenylboronic acid