methyl 6-((S)-7-((S)-2-(tert-butoxycarbonylamino)-3-(4-hydroxyphenyl)propanoyl)-1,4-dithia-7-azaspiro[4.4]nonane-8-carboxamido)hexanoate

Base Information

Chemical Name:methyl 6-((S)-7-((S)-2-(tert-butoxycarbonylamino)-3-(4-hydroxyphenyl)propanoyl)-1,4-dithia-7-azaspiro[4.4]nonane-8-carboxamido)hexanoate
CAS No.:1286721-65-0
Molecular Formula:C₂₈H₄₁N₃O₇S₂
Molecular Weight:595.781
Hs Code.:

Synonyms:methyl 6-((S)-7-((S)-2-(tert-butoxycarbonylamino)-3-(4-hydroxyphenyl)propanoyl)-1,4-dithia-7-azaspiro[4.4]nonane-8-carboxamido)hexanoate

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Chemical Property of methyl 6-((S)-7-((S)-2-(tert-butoxycarbonylamino)-3-(4-hydroxyphenyl)propanoyl)-1,4-dithia-7-azaspiro[4.4]nonane-8-carboxamido)hexanoate

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Technology Process of methyl 6-((S)-7-((S)-2-(tert-butoxycarbonylamino)-3-(4-hydroxyphenyl)propanoyl)-1,4-dithia-7-azaspiro[4.4]nonane-8-carboxamido)hexanoate

There total 8 articles about methyl 6-((S)-7-((S)-2-(tert-butoxycarbonylamino)-3-(4-hydroxyphenyl)propanoyl)-1,4-dithia-7-azaspiro[4.4]nonane-8-carboxamido)hexanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 51.0%

: 1286721-79-6
(S)-methyl 6-(1,4-dithia-7-azaspiro[4.4]nonane-8-carboxamido)hexanoate

: 3978-80-1
Boc-Tyr-OH

: 1286721-65-0
methyl 6-((S)-7-((S)-2-(tert-butoxycarbonylamino)-3-(4-hydroxyphenyl)propanoyl)-1,4-dithia-7-azaspiro[4.4]nonane-8-carboxamido)hexanoate

Guidance literature:: Boc-Tyr-OH; With O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; triethylamine; In tetrahydrofuran; at 20 ℃; for 0.25h;

(S)-methyl 6-(1,4-dithia-7-azaspiro[4.4]nonane-8-carboxamido)hexanoate; In tetrahydrofuran; at 20 ℃; for 8h;
DOI:10.1016/j.ejmech.2011.08.045

Reference yield:

: 24424-99-5
di-tert-butyl dicarbonate

: 1286721-65-0
methyl 6-((S)-7-((S)-2-(tert-butoxycarbonylamino)-3-(4-hydroxyphenyl)propanoyl)-1,4-dithia-7-azaspiro[4.4]nonane-8-carboxamido)hexanoate

Guidance literature:: Multi-step reaction with 2 steps

1.1: sodium hydroxide / tetrahydrofuran; water / 6 h / 20 °C / pH 9 - 11

1.2: pH 4 - 5

2.1: O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; triethylamine / tetrahydrofuran / 0.25 h / 20 °C

2.2: 8 h / 20 °C

With O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; triethylamine; sodium hydroxide; In tetrahydrofuran; water;
DOI:10.1016/j.ejmech.2011.08.045

Reference yield:

: 1286721-19-4
(S)-tert-butyl 8-(6-methoxy-6-oxohexylcarbamoyl)-1,4-dithia-7-azaspiro[4.4]nonane-7-carboxylate

: 1286721-65-0
methyl 6-((S)-7-((S)-2-(tert-butoxycarbonylamino)-3-(4-hydroxyphenyl)propanoyl)-1,4-dithia-7-azaspiro[4.4]nonane-8-carboxamido)hexanoate

Guidance literature:: Multi-step reaction with 2 steps

1.1: trifluoroacetic acid / dichloromethane

2.1: O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; triethylamine / tetrahydrofuran / 0.25 h / 20 °C

2.2: 8 h / 20 °C

With O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; triethylamine; trifluoroacetic acid; In tetrahydrofuran; dichloromethane;
DOI:10.1016/j.ejmech.2011.08.045