N-cyclopropyl-4-[4-(3,5-dichlorophenyl)-4-(trifluoromethyl)-3H-pyrazol-2-yl]-2-methylbenzamide

Base Information

Chemical Name:N-cyclopropyl-4-[4-(3,5-dichlorophenyl)-4-(trifluoromethyl)-3H-pyrazol-2-yl]-2-methylbenzamide
CAS No.:1620722-81-7
Molecular Formula:C₂₁H₁₈Cl₂F₃N₃O
Molecular Weight:456.295
Hs Code.:

Synonyms:N-cyclopropyl-4-[4-(3,5-dichlorophenyl)-4-(trifluoromethyl)-3H-pyrazol-2-yl]-2-methylbenzamide

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of N-cyclopropyl-4-[4-(3,5-dichlorophenyl)-4-(trifluoromethyl)-3H-pyrazol-2-yl]-2-methylbenzamide

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Technology Process of N-cyclopropyl-4-[4-(3,5-dichlorophenyl)-4-(trifluoromethyl)-3H-pyrazol-2-yl]-2-methylbenzamide

There total 5 articles about N-cyclopropyl-4-[4-(3,5-dichlorophenyl)-4-(trifluoromethyl)-3H-pyrazol-2-yl]-2-methylbenzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 22.0%

: 345965-99-3
4-bromo-N-cyclopropyl-2-methylbenzamide

: 1620722-95-3
4-(3,5-dichlorophenyl)-4-(trifluoromethyl)-1,5-dihydropyrazole

: 1620722-81-7
N-cyclopropyl-4-[4-(3,5-dichlorophenyl)-4-(trifluoromethyl)-3H-pyrazol-2-yl]-2-methylbenzamide

Guidance literature:: With palladium diacetate; caesium carbonate; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; In toluene; at 80 ℃; for 3h; Inert atmosphere;

Reference yield:

: 1620722-93-1
1,3-dichloro-5-[(Z)-2-nitro-1-(trifluoromethyl)vinyl]benzene

: 1620722-81-7
N-cyclopropyl-4-[4-(3,5-dichlorophenyl)-4-(trifluoromethyl)-3H-pyrazol-2-yl]-2-methylbenzamide

Guidance literature:: Multi-step reaction with 3 steps

1: sodium ethanolate / ethanol / 20 °C

2: zinc; acetic acid / methanol / 1 h / Reflux

3: palladium diacetate; caesium carbonate; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene / toluene / 3 h / 80 °C / Inert atmosphere

With sodium ethanolate; palladium diacetate; caesium carbonate; acetic acid; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; zinc; In methanol; ethanol; toluene; 3: |Buchwald-Hartwig Coupling;

Reference yield:

: 1620722-94-2
1,3-dichloro-5-[2,2,2-trifluoro-1,1-bis(nitromethyl)ethyl]benzene

: 1620722-81-7
N-cyclopropyl-4-[4-(3,5-dichlorophenyl)-4-(trifluoromethyl)-3H-pyrazol-2-yl]-2-methylbenzamide

Guidance literature:: Multi-step reaction with 2 steps

1: zinc; acetic acid / methanol / 1 h / Reflux

2: palladium diacetate; caesium carbonate; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene / toluene / 3 h / 80 °C / Inert atmosphere

With palladium diacetate; caesium carbonate; acetic acid; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; zinc; In methanol; toluene; 2: |Buchwald-Hartwig Coupling;