cyclopentanecarboxylic acid {3-[2-(3-acetylamino-phenylamino)-5-cyclopropyl-pyrimidin-4-ylamino]-propyl}-amide

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Chemical Name:cyclopentanecarboxylic acid {3-[2-(3-acetylamino-phenylamino)-5-cyclopropyl-pyrimidin-4-ylamino]-propyl}-amide
CAS No.:1190378-18-7
Molecular Formula:C₂₄H₃₂N₆O₂
Molecular Weight:436.557
Hs Code.:

Synonyms:cyclopentanecarboxylic acid {3-[2-(3-acetylamino-phenylamino)-5-cyclopropyl-pyrimidin-4-ylamino]-propyl}-amide

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of cyclopentanecarboxylic acid {3-[2-(3-acetylamino-phenylamino)-5-cyclopropyl-pyrimidin-4-ylamino]-propyl}-amide

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Technology Process of cyclopentanecarboxylic acid {3-[2-(3-acetylamino-phenylamino)-5-cyclopropyl-pyrimidin-4-ylamino]-propyl}-amide

There total 5 articles about cyclopentanecarboxylic acid {3-[2-(3-acetylamino-phenylamino)-5-cyclopropyl-pyrimidin-4-ylamino]-propyl}-amide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 44.0%

: N-{3-[4-(3-aminopropylamino)-5-cyclopropyl-pyrimidin-2-ylamino]-phenyl}-acetamide dihydrochloride

: 3400-45-1
cyclopentanecarboxylic acid

: 1190378-18-7
cyclopentanecarboxylic acid {3-[2-(3-acetylamino-phenylamino)-5-cyclopropyl-pyrimidin-4-ylamino]-propyl}-amide

Guidance literature:: With N-ethyl-N,N-diisopropylamine; HATU; In N,N-dimethyl-formamide; at 20 ℃; for 1.5h;

Reference yield:

: 1190379-86-2
2,4-dichloro-5-cyclopropylpyrimidine

: 1190378-18-7
cyclopentanecarboxylic acid {3-[2-(3-acetylamino-phenylamino)-5-cyclopropyl-pyrimidin-4-ylamino]-propyl}-amide

Guidance literature:: Multi-step reaction with 4 steps

1: N-ethyl-N,N-diisopropylamine / isopropyl alcohol / 1 h / 0 °C

2: acetic acid / butan-1-ol / 0.25 h / 140 °C / Microwave irradiation

3: hydrogenchloride / 1,4-dioxane / 2 h / 20 °C

4: N-ethyl-N,N-diisopropylamine; HATU / N,N-dimethyl-formamide / 1.5 h / 20 °C

With hydrogenchloride; acetic acid; N-ethyl-N,N-diisopropylamine; HATU; In 1,4-dioxane; N,N-dimethyl-formamide; isopropyl alcohol; butan-1-ol;

Reference yield:

: 1190379-87-3
[3-(2-chloro-5-cyclopropyl-pyrimidin-4-ylamino)-propyl]-carbamic acid tert-butyl ester

: 1190378-18-7
cyclopentanecarboxylic acid {3-[2-(3-acetylamino-phenylamino)-5-cyclopropyl-pyrimidin-4-ylamino]-propyl}-amide

Guidance literature:: Multi-step reaction with 3 steps

1: acetic acid / butan-1-ol / 0.25 h / 140 °C / Microwave irradiation

2: hydrogenchloride / 1,4-dioxane / 2 h / 20 °C

3: N-ethyl-N,N-diisopropylamine; HATU / N,N-dimethyl-formamide / 1.5 h / 20 °C

With hydrogenchloride; acetic acid; N-ethyl-N,N-diisopropylamine; HATU; In 1,4-dioxane; N,N-dimethyl-formamide; butan-1-ol;