ethyl 1-(3-nitrophenyl)-3-methyl-5-pyrazole carboxylate

Base Information

• Chemical Name: ethyl 1-(3-nitrophenyl)-3-methyl-5-pyrazole carboxylate
• CAS No.: 209959-75-1
• Molecular Formula: C₁₃H₁₃N₃O₄
• Molecular Weight: 275.264
• Mol file: 209959-75-1.mol

Synonyms:ethyl 1-(3-nitrophenyl)-3-methyl-5-pyrazole carboxylate

Chemical Property of ethyl 1-(3-nitrophenyl)-3-methyl-5-pyrazole carboxylate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of ethyl 1-(3-nitrophenyl)-3-methyl-5-pyrazole carboxylate

There total 2 articles about ethyl 1-(3-nitrophenyl)-3-methyl-5-pyrazole carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

3-nitrophenylhydrazine hydrochloride (51516-96-2,636-95-3) + 1,1,1-trichloro-4-methoxy-3-penten-2-one (135351-18-7,83124-77-0) → ethyl 1-(3-nitrophenyl)-3-methyl-5-pyrazole carboxylate (209959-75-1)

Guidance literature:

In ethanol; for 12h; Reflux;

Reference yield:

3-nitrophenylhydrazine (619-27-2) + 2-methoxyimino-4-oxo-pentaneperoxoic acid ethyl ester (82874-96-2) → ethyl 1-(3-nitrophenyl)-3-methyl-5-pyrazole carboxylate (209959-75-1)

Guidance literature:

In ethanol; for 5h; Heating;

DOI:10.1021/jm020578e

Reference yield:

4-(2'-tert-butylaminosulfonylphenyl)aniline (193006-34-7) + ethyl 1-(3-nitrophenyl)-3-methyl-5-pyrazole carboxylate (209959-75-1) → 1-(3-nitrophenyl)-3-methyl-5-[(2'-tert-butylaminosulfonyl-[1,1']-biphen-4-yl)aminocarbonyl]pyrazole (209959-76-2)

Guidance literature:

4-(2'-tert-butylaminosulfonylphenyl)aniline; With trimethylaluminum; In hexane; dichloromethane; at 20 ℃; for 0.25h;

ethyl 1-(3-nitrophenyl)-3-methyl-5-pyrazole carboxylate; In hexane; dichloromethane; at 40 ℃; for 18h;

DOI:10.1021/jm020578e

upstream raw materials:

3-nitrophenylhydrazine

2-methoxyimino-4-oxo-pentaneperoxoic acid ethyl ester

3-nitrophenylhydrazine hydrochloride

1,1,1-trichloro-4-methoxy-3-penten-2-one

Downstream raw materials:

1-(3-nitrophenyl)-3-methyl-5-[(2'-tert-butylaminosulfonyl-[1,1']-biphen-4-yl)aminocarbonyl]pyrazole

N-[2'-(aminosulfonyl)-1,1'-biphenyl-4-yl]-3-methyl-1-(3-nitrophenyl)-1H-pyrazole-5-carboxamide

Refernces

• 1、 Lam, Patrick Y. S.,Clark, Charles G.,Li, Renhua,Pinto, Donald J. P.,Orwat, Michael J.,Galemmo, Robert A.,Fevig, John M.,Teleha, Christopher A.,Alexander, Richard S.,Smallwood, Angela M.,Rossi, Karen A.,Wright, Matthew R.,Bai, Stephen A.,He, Kan,Luettgen, Joseph M.,Wong, Pancras C.,Knabb, Robert M.,Wexler, Ruth R.. "Structure-based design of novel guanidine/benzamidine mimics: Potent and orally bioavailable factor Xa inhibitors as novel anticoagulants". . p. 4405 - 4418. Retrieved 2007/10/03.