8-amino-1-(2,4-dichloro-phenyl)-1,4,5,6-tetrahydro-1,2-diaza-benzo[e]azulene-3-carboxylic acid piperidin-1-ylamide

Base Information

• Chemical Name: 8-amino-1-(2,4-dichloro-phenyl)-1,4,5,6-tetrahydro-1,2-diaza-benzo[e]azulene-3-carboxylic acid piperidin-1-ylamide
• CAS No.: 494844-06-3
• Molecular Formula: C₂₄H₂₅Cl₂N₅O
• Molecular Weight: 470.401

Synonyms:8-amino-1-(2,4-dichloro-phenyl)-1,4,5,6-tetrahydro-1,2-diaza-benzo[e]azulene-3-carboxylic acid piperidin-1-ylamide

Chemical Property of 8-amino-1-(2,4-dichloro-phenyl)-1,4,5,6-tetrahydro-1,2-diaza-benzo[e]azulene-3-carboxylic acid piperidin-1-ylamide

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Technology Process of 8-amino-1-(2,4-dichloro-phenyl)-1,4,5,6-tetrahydro-1,2-diaza-benzo[e]azulene-3-carboxylic acid piperidin-1-ylamide

There total 6 articles about 8-amino-1-(2,4-dichloro-phenyl)-1,4,5,6-tetrahydro-1,2-diaza-benzo[e]azulene-3-carboxylic acid piperidin-1-ylamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

N-piperidin-1-yl-1-(2′,4′-dichlorophenyl)-8-nitro-1,4,5,6-tetrahydrobenzo[6,7]cyclohepta[1,2-c]pyrazole-3-carboxamide (494844-04-1) → 8-amino-1-(2,4-dichloro-phenyl)-1,4,5,6-tetrahydro-1,2-diaza-benzo[e]azulene-3-carboxylic acid piperidin-1-ylamide (494844-06-3)

Guidance literature:

With hydrogenchloride; iron; In ethanol; at 65 ℃; for 3h;

DOI:10.1248/cpb.50.1109

Reference yield:

1-Aminopiperidine (2213-43-6) → 8-amino-1-(2,4-dichloro-phenyl)-1,4,5,6-tetrahydro-1,2-diaza-benzo[e]azulene-3-carboxylic acid piperidin-1-ylamide (494844-06-3)

Guidance literature:

Multi-step reaction with 2 steps

1.1: HNO₃; AcOH / 20 °C

1.2: 52 percent / HBTU / acetonitrile; diisopropyl ether / 20 °C

2.1: 91 percent / Fe; aq. HCl / ethanol / 3 h / 65 °C

With hydrogenchloride; nitric acid; iron; acetic acid; In ethanol;

DOI:10.1248/cpb.50.1109

Reference yield:

1-(2′-4′-dichlorophenyl)-1,4,5,6-tetrahydrobenzo[6,7]cyclohepta[1,2-c]pyrazole-3-carboxylic acid (337526-59-7) → 8-amino-1-(2,4-dichloro-phenyl)-1,4,5,6-tetrahydro-1,2-diaza-benzo[e]azulene-3-carboxylic acid piperidin-1-ylamide (494844-06-3)

Guidance literature:

Multi-step reaction with 2 steps

1.1: HNO₃; AcOH / 20 °C

1.2: 52 percent / HBTU / acetonitrile; diisopropyl ether / 20 °C

2.1: 91 percent / Fe; aq. HCl / ethanol / 3 h / 65 °C

With hydrogenchloride; nitric acid; iron; acetic acid; In ethanol;

DOI:10.1248/cpb.50.1109

upstream raw materials:

N-piperidin-1-yl-1-(2′,4′-dichlorophenyl)-8-nitro-1,4,5,6-tetrahydrobenzo[6,7]cyclohepta[1,2-c]pyrazole-3-carboxamide

2,4-dichlorophenyl hydrazine hydrochloride

1-Aminopiperidine

1-Benzosuberone

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