(+)-phantasmidine Mosher's amide

Base Information

Chemical Name:(+)-phantasmidine Mosher's amide
CAS No.:1380584-11-1
Molecular Formula:C₂₁H₁₈ClF₃N₂O₃
Molecular Weight:438.834
Hs Code.:

Synonyms:(+)-phantasmidine Mosher's amide

Suppliers and Price of (+)-phantasmidine Mosher's amide

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Chemical Property of (+)-phantasmidine Mosher's amide

Chemical Property:

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Technology Process of (+)-phantasmidine Mosher's amide

There total 10 articles about (+)-phantasmidine Mosher's amide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: (2aR,4aS,9aS)-7-chloro-1,2,2a,3,4,4a-hexahydrobenzofuro[2,3-c]cyclobuta[b]pyrrole

: 20445-33-4,39637-99-5
(R)-methoxytrifluoromethylphenylacetyl chloride

: 1380584-11-1
(+)-phantasmidine Mosher's amide

Guidance literature:: With pyridine; In chloroform-d1; at 25 ℃; for 1h; Inert atmosphere;

Reference yield:

: 20885-12-5
2-chloro-6-fluoropyridine

: 1380584-11-1
(+)-phantasmidine Mosher's amide

Guidance literature:: Multi-step reaction with 10 steps

1.1: diisopropylamine; n-butyllithium / tetrahydrofuran; hexanes / 1 h / -78 °C / Inert atmosphere

1.2: 1 h / -78 °C / Inert atmosphere

2.1: sodium tetrahydroborate / methanol / 0.08 h / -10 °C / Inert atmosphere

2.2: pH 1 / Inert atmosphere

3.1: thionyl chloride / N,N-dimethyl-formamide / dichloromethane / 6 h / 0 - 25 °C / Inert atmosphere

4.1: dimethyl sulfoxide / 1.17 h / 25 °C / Inert atmosphere

5.1: methanesulfonic acid; aluminum oxide / 0.25 h / 120 °C / Inert atmosphere

6.1: hydrogenchloride / diethyl ether / 2 h / 80 °C / Sealed tube; Inert atmosphere

7.1: potassium hydroxide / water; tert-butyl alcohol / 0.25 h / 25 °C / Inert atmosphere

8.1: borane-THF / tetrahydrofuran / 30.08 h / 0 - 25 °C / Inert atmosphere

8.2: 0.08 h / 0 °C / Inert atmosphere

8.3: 3 h / Inert atmosphere; Reflux

9.1: Daicel Chiralcel OJ-H column / isopropyl alcohol; hexane / Resolution of racemate

10.1: pyridine / chloroform-d1 / 1 h / 25 °C / Inert atmosphere

With pyridine; hydrogenchloride; aluminum oxide; sodium tetrahydroborate; n-butyllithium; thionyl chloride; borane-THF; methanesulfonic acid; diisopropylamine; potassium hydroxide; N,N-dimethyl-formamide; In tetrahydrofuran; methanol; hexanes; diethyl ether; chloroform-d1; hexane; dichloromethane; water; dimethyl sulfoxide; isopropyl alcohol; tert-butyl alcohol;

Reference yield:

: 1093880-37-5
6-chloro-2-fluoropyridine-3-carboxaldehyde

: 1380584-11-1
(+)-phantasmidine Mosher's amide

Guidance literature:: Multi-step reaction with 9 steps

1.1: sodium tetrahydroborate / methanol / 0.08 h / -10 °C / Inert atmosphere

1.2: pH 1 / Inert atmosphere

2.1: thionyl chloride / N,N-dimethyl-formamide / dichloromethane / 6 h / 0 - 25 °C / Inert atmosphere

3.1: dimethyl sulfoxide / 1.17 h / 25 °C / Inert atmosphere

4.1: methanesulfonic acid; aluminum oxide / 0.25 h / 120 °C / Inert atmosphere

5.1: hydrogenchloride / diethyl ether / 2 h / 80 °C / Sealed tube; Inert atmosphere

6.1: potassium hydroxide / water; tert-butyl alcohol / 0.25 h / 25 °C / Inert atmosphere

7.1: borane-THF / tetrahydrofuran / 30.08 h / 0 - 25 °C / Inert atmosphere

7.2: 0.08 h / 0 °C / Inert atmosphere

7.3: 3 h / Inert atmosphere; Reflux

8.1: Daicel Chiralcel OJ-H column / isopropyl alcohol; hexane / Resolution of racemate

9.1: pyridine / chloroform-d1 / 1 h / 25 °C / Inert atmosphere

With pyridine; hydrogenchloride; aluminum oxide; sodium tetrahydroborate; thionyl chloride; borane-THF; methanesulfonic acid; potassium hydroxide; N,N-dimethyl-formamide; In tetrahydrofuran; methanol; diethyl ether; chloroform-d1; hexane; dichloromethane; water; dimethyl sulfoxide; isopropyl alcohol; tert-butyl alcohol;