benzyl (1R,2S)-1-((S)-2,2-dimethyl-1,3-dioxolan-4-yl)-2-(trifluoromethyl)butylcarbamate

Base Information

Chemical Name:benzyl (1R,2S)-1-((S)-2,2-dimethyl-1,3-dioxolan-4-yl)-2-(trifluoromethyl)butylcarbamate
CAS No.:888725-55-1
Molecular Formula:C₁₈H₂₄F₃NO₄
Molecular Weight:375.388
Hs Code.:

Synonyms:benzyl (1R,2S)-1-((S)-2,2-dimethyl-1,3-dioxolan-4-yl)-2-(trifluoromethyl)butylcarbamate

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Chemical Property of benzyl (1R,2S)-1-((S)-2,2-dimethyl-1,3-dioxolan-4-yl)-2-(trifluoromethyl)butylcarbamate

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Technology Process of benzyl (1R,2S)-1-((S)-2,2-dimethyl-1,3-dioxolan-4-yl)-2-(trifluoromethyl)butylcarbamate

There total 4 articles about benzyl (1R,2S)-1-((S)-2,2-dimethyl-1,3-dioxolan-4-yl)-2-(trifluoromethyl)butylcarbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

: 888725-53-9
(1R,2S)-1-((S)-2,2-dimethyl-1,3-dioxolan-4-yl)-2-(trifluoromethyl)butan-1-amine

: 501-53-1,94274-21-2
benzyl chloroformate

: 888725-55-1
benzyl (1R,2S)-1-((S)-2,2-dimethyl-1,3-dioxolan-4-yl)-2-(trifluoromethyl)butylcarbamate

Guidance literature:: With sodium hydrogencarbonate; In tetrahydrofuran; at 20 ℃; for 2h;
DOI:10.1021/jo0601157

Reference yield:

: 888725-51-7
(1R,2S)-N-benzyl-1-((S)-2,2-dimethyl-1,3-dioxolan-4-yl)-2-(trifluoromethyl)but-3-en-1-amine

: 888725-55-1
benzyl (1R,2S)-1-((S)-2,2-dimethyl-1,3-dioxolan-4-yl)-2-(trifluoromethyl)butylcarbamate

Guidance literature:: Multi-step reaction with 2 steps

1: 89 percent / H₂ / Pd/C / ethyl acetate / 4 h / 20 °C

2: 93 percent / aq. NaHCO₃ / tetrahydrofuran / 2 h / 20 °C

With hydrogen; sodium hydrogencarbonate; palladium on activated charcoal; In tetrahydrofuran; ethyl acetate;
DOI:10.1021/jo0601157

Reference yield:

: 100777-91-1
(2S)-2,3-O-isopropylideneglyceraldehyde N-benzylimine

: 888725-55-1
benzyl (1R,2S)-1-((S)-2,2-dimethyl-1,3-dioxolan-4-yl)-2-(trifluoromethyl)butylcarbamate

Guidance literature:: Multi-step reaction with 3 steps

1: 61 percent / In powder / dimethylformamide / 15 h / 20 °C

2: 89 percent / H₂ / Pd/C / ethyl acetate / 4 h / 20 °C

3: 93 percent / aq. NaHCO₃ / tetrahydrofuran / 2 h / 20 °C

With indium; hydrogen; sodium hydrogencarbonate; palladium on activated charcoal; In tetrahydrofuran; ethyl acetate; N,N-dimethyl-formamide;
DOI:10.1021/jo0601157